| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Internal Medicine, The University of Texas Southwestern Medical School Dallas, Texas75235
This work was aided by a grant from the U.S. Public Health Service (AM-03892). It was presented at the IV International Congress of Endocrinology and has been published in abstract form (1).
Abstract
To assess the capacity of different androgens to virilize the urogenital tracts of female rat embryos, pregant rats were given varying amounts of ten steroids from day 14 of gestation until day 21. The newborn from these mothers were given 1/25 of the maternal dosage on days 1 and 3 after birth and killed on day 4. The urogenital tracts of the female embryos were assessed for the presence of the epididymis, vas deferens, seminal vesicle, and prostate. Dihydrotestosterone administration invariably produced bilateral virilization of the female urogenital tract when the maternal dosage was 8 mg/day, whereas methyltestosterone, methyldihydrotestosterone, and 3
, 17β-androstanediol produced equally marked masculinization at a 4 mg/day dosage. No virilization was noted following treatment with 5β-dihydrotestosterone, androstenedione, 3β,17β-androstanedione, or androsterone. Testosterone in these dosages caused fetal resorption. These findings, considered together with recent studies of androgen metabolism and binding in fetal tissues, have been interpreted as support for the concept that dihydrotestosterone is the active androgen that induces male differentiation of the urogenital sinus. Furthermore, although testosterone itself probably induces virilization of the wolfnan ducts under normal physiological conditions, the finding that 5βreduced androgens share this capacity indicates that the critical receptor mechanisms in the wolffian duct are not specific for 
4-3-ketosteroids. (Endocrinology 94: 979, 1974)
Received May 14, 1973.
This article has been cited by other articles:
 |
|
 |
|
  G. Shaw, J. Fenelon, M. Sichlau, R. J. Auchus, J. D. Wilson, and M. B. Renfree Role of the Alternate Pathway of Dihydrotestosterone Formation in Virilization of the Wolffian Ducts of the Tammar Wallaby, Macropus eugenii Endocrinology, May 1, 2006; 147(5): 2368 - 2373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K-M Fung, E N S Samara, C Wong, A Metwalli, R Krlin, B Bane, C Z Liu, J T Yang, J V Pitha, D J Culkin, et al. Increased expression of type 2 3{alpha}-hydroxysteroid dehydrogenase/type 5 17{beta}-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. Endocr. Relat. Cancer, March 1, 2006; 13(1): 169 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Wolf, G. A. LeBlanc, and L. E. Gray Jr. Interactive Effects of Vinclozolin and Testosterone Propionate on Pregnancy and Sexual Differentiation of the Male and Female SD Rat Toxicol. Sci., March 1, 2004; 78(1): 135 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Rizner, H. K. Lin, D. M. Peehl, S. Steckelbroeck, D. R. Bauman, and T. M. Penning Human Type 3 3{alpha}-Hydroxysteroid Dehydrogenase (Aldo-Keto Reductase 1C2) and Androgen Metabolism in Prostate Cells Endocrinology, July 1, 2003; 144(7): 2922 - 2932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Mazza, I. Di Monte, P.L. Ceccarelli, F. Rivasi, C. Falcinelli, A. Forabosco, and A. Volpe Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: Case report Hum. Reprod., March 1, 2002; 17(3): 821 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Wolf, A. Hotchkiss, J. S. Ostby, G. A. LeBlanc, and L. E. Gray Jr. Effects of Prenatal Testosterone Propionate on the Sexual Development of Male and Female Rats: A Dose-Response Study Toxicol. Sci., January 1, 2002; 65(1): 71 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Su, X. Chai, B. Kahn, and J. L. Napoli cDNA Cloning, Tissue Distribution, and Substrate Characteristics of a cis-Retinol/3alpha -Hydroxysterol Short-chain Dehydrogenase Isozyme J. Biol. Chem., July 10, 1998; 273(28): 17910 - 17916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chai, Y. Zhai, and J. L. Napoli cDNA Cloning and Characterization of a cis-Retinol/3alpha -Hydroxysterol Short-chain Dehydrogenase J. Biol. Chem., December 26, 1997; 272(52): 33125 - 33131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Biswas and D. W. Russell Expression Cloning and Characterization of Oxidative 17beta - and 3alpha -Hydroxysteroid Dehydrogenases from Rat and Human Prostate J. Biol. Chem., June 20, 1997; 272(25): 15959 - 15966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P van der Schoot Foetal testes control the prenatal growth and differentiation of the gubernacular cones in rabbits--a tribute to the late Professor Alfred Jost Development, January 8, 1993; 118(4): 1327 - 1334. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Wilson, F. George, and J. Griffin The hormonal control of sexual development Science, March 20, 1981; 211(4488): 1278 - 1284. [PDF]
|
|
|
|
 |
|
 G. Shaw, M. B. Renfree, M. W. Leihy, C. H. L. Shackleton, E. Roitman, and J. D. Wilson Prostate formation in a marsupial is mediated by the testicular androgen 5alpha -androstane-3alpha ,17beta -diol PNAS, October 24, 2000; 97(22): 12256 - 12259. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
