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Department of Obstetrics and Gynecology and Department of Biology, West Virginia University Morgantown, West Virginia 26506
Abstract
Groups of female rats were decapitated at 3-hr intervals throughout 4-day estrous cycles and the plasma of each rat was assayed for LH, FSH, prolactin, progesterone and estradiol-17β. Radioimmunoassays were used to measure these hormones, except for progesterone which was determined by the competitive protein binding assay. All five hormones exhibited a peak concentration in plasma on the day of proestrus. In addition, progesterone was elevated from 0900 hr of metestrus to 0900 hr of diestrus, while plasma prolactin showed a brief rise at 1500 hr of estrus. The elevated level of estradiol on the day of proestrus followed a different pattern than the other four hormones. Estradiol concentration began to rise late on metestrus, reached a peak at noon of proestrus, and fell before peak levels of the other hormones were reached. The preovulatory elevation of LH, prolactin and progesterone occurred between noon and midnight of proestrus, while the peak of FSH lasted from noon of proestrus to noon of estrus. (Endocrinology 94: 1704, 1974)
Footnotes
1 The research was supported in part by a grant from the National Science Foundation (GB-22605).
2 Address reprint requests to: Dr. R. L. Butcher, Department of Obstetrics and Gynecology, West Virginia University Medical Center, Morgantown, West Virginia 26506.
Received November 12, 1973.
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L. A. Akinola, M. Poutanen, R. Vihko, and P. Vihko Expression of 17{beta}-Hydroxysteroid Dehydrogenase Type 1 and Type 2, P450 Aromatase, and 20{alpha}-Hydroxysteroid Dehydrogenase Enzymes in Immature, Mature, and Pregnant Rats Endocrinology, July 1, 1997; 138(7): 2886 - 2892. [Abstract] [Full Text] [PDF] |
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D. Mitsushima, K. Jinnai, and F. Kimura Possible Role of the {gamma}-Aminobutyric Acid-A Receptor System in the Timing of the Proestrous Luteinizing Hormone Surge in Rats Endocrinology, May 1, 1997; 138(5): 1944 - 1948. [Abstract] [Full Text] [PDF] |
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M Bengtsson and J Rydstrom Regulation of carcinogen metabolism in the rat ovary by the estrous cycle and gonadotropin Science, March 25, 1983; 219(4591): 1437 - 1438. [Abstract] [PDF] |
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S. Ch. Papasozomenos and A. Shanavas Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau : Implications for Alzheimer's disease PNAS, February 5, 2002; 99(3): 1140 - 1145. [Abstract] [Full Text] [PDF] |
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