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Episodic Secretion of Renin

Department of Physiology, School of Medicine, Case Western Reserve University Cleveland,Ohio 44106

This work was supported by U.S. Public Health Services Grant HL 13062 and Training Grant GM 00899.

Abstract

Renin is secreted episodically in the absence of overt stimulation in the pentobarbitalanesthetized, saline-loaded cat. Ninety min postlaparotomy, arterial and renal venous plasma renin concentrations (PRC) were determined at 15-min intervals for a 2-hr period. The pattern of renin secretion consisted of significant secretory peaks and periods in which little or no renin was secreted. In only a few instances could renin secretion be attributedto a preceding arterial blood pressure drop. The secretory episodes were also dissociated from flow. (Endocrinology 96:129, 1974)

Received April 18, 1974.