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Endocrinology, doi:10.1210/endo-96-1-135
Endocrinology Vol. 96, No. 1 135-142
Copyright © 1975 by the Endocrine Society.
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LH-RH-Containing Neural Elements in the Rat Hypothalamus1

G. SÉTÁLó, S. VIGH, A.V. SCHALLY, A. ARIMURA and B. FLERKó

Department of Anatomy, University Medical School, Pecs, Hungary, and Department of Medicine, Tulane University School of Medicine, and Endocrine and Polypeptide Laboratories, VA Hospital, New Orleans, Louisiana 70146

Abstract

With the use of rabbit anti-LH-RH serum, a system of delicate nerve fibers and terminals which contain immunoreactive LH-RH can be demonstrated in the median eminence of the rat,corresponding exactly to the tubero-infundibular tract as described earlier with the aid of classical neurohistological methods. The delicate fiber system can be traced to the region of the retrochiasmatic area and especially to that of the arcuate nucleus but not farther. Nerve cells do not show any immunopositive reaction for LH-RH in the experimental conditions studied. LH-RH positive nerve fibers terminate on or in the immediate vicinity of the capillary loops penetrating the median eminence. (Endocrinology96: 135, 1975)

Footnotes

1 This work was supported in part by Population Council Grant No. M72.85 and USPHS Research Grants AM-09094, HD-06555, AM-07467, and VA Administration.

Received May 2, 1974.




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Copyright © 1975 by The Endocrine Society