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The Clearance of ACTH from the Plasma of Adult and Fetal Sheep

Nuffield Institute for Medical Research, University of Oxford, Headley Way Oxford 0X3 9DS, England

Abstract

The disappearance of ¹²⁵I-ACTH from the circulation of 4 pregnant and fetal sheep has been followed after a single injection to the ewe or fetus. The mean metabolic clearance rate for the fetus and the ewe was 55 and 34 ml/min/kg respectively, giving a half-life in each case of about 1 min. The higher fetal than maternal arterial plasma ACTH concentration has been ascribed to a higher rate of secretion rather than a reduced rate of clearance compared with the ewe. There was no evidence of placental transfer of immunologically reactive ACTH. (Endocrinology 96:231, 1975).

Footnotes

^* Present address: Department of Obstetrics and Gynecology, Memorial University of Newfoundland, St. John, s, Newfoundland, Canada.

^* Department of Obstetrics and Gynecology, Queens University Kingston, Ontario, Canada.

Received March 13, 1974.