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Identification and Measurement of Urinary Estrone, Estradiol-17β, Estriol, Pregnanediol and Androsterone During the Menstrual Cycle of the Orangutan¹

Department of Medicine, Emory University School of Medicine and Yerkes Primate Center Atlanta, Georgia, 30322

Abstract

Urinary estrone, estradiol-17β, estriol, pregnanediol and androsterone wereidentified and measured during 3 menstrual cycles in 2 female orangutans. In 2 of the cycles, the animals excreted 1–8 µg/day estrone, 0.5–6 µng/day estradiol–17β3, 1–8 tigµday estriol, 20–206 µg/day pregnanediol and 120–522 µg/day androsterone during the first half of the menstrual cycle. In the second half of the cycle, corresponding values were 3–21 µg/day estrone, 2–10 µg/day estradiol-17β, 1–9 µg/day estriol, 54–800 µg/day pregnanediol and 90–1158 µg/day androsterone. In 1 cycle, the estrogen values for thesecond half were considerably higher, possibly due to the animal becoming pregnant just before this study commenced. The valuesfor estrone and estradiol-17β are similar to those found in the human and chimpanzee menstrual cycle. The values for estriol were lower than in the human but higher than in the chimpanzee. Levels for urinary pregnanediol and androsterone were significantly lower than in the human. Variations during the menstrual cycle for estrone were characterized by a midcycle peak followed by a second peak in the luteal phase. No definite pattern was apparent for estradiol-17µ or estriol. Both urinary pregnanediol and androsterone levels were low during the first half of the cycle, started to rise just after midcycle, and showed a peak during the second half of the menstrual cycle. (Endocrinology 96: 93, 1975)

Footnotes

¹ This study was supported by the following research grants: Ford Foundation Grant 690-0645; U.S.P.H.S., Grant RR 00165 from the Animal Resources Branch of NIH to the Yerkes Primate Center and U.S.P.H.S. Grant 5-R01-AM0221.

² Recipient of U.S.P.H.S. Career Research Development Award 1-K04-AM-70381-01 from the National Institute of Arthritis, Digestive and Metabolic Diseases.

³ Address reprint requests to: Dr. D. C. Collins, Dept. of Medicine, Emory University School of Medicine, 69 Butler Street, S.E., Atlanta, Georgia 30303.

Received April 17, 1974.

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