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Regulation of FSH Secretion: Use of Hydroxyurea to Deplete Germinal Epithelium

Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health Bethesda, Maryland 20014

Abstract

Hydroxyurea, a chemotherapeutic agent that prevents mitosis by inhibiting DNA synthesis, was administered to adult male rats for 70 days. Plasma FSH and LH showed no systematic trend although severe germinal cell depletion was produced. These data suggest that the cell(s) of the seminiferous tubule involved in FSH regulation must be either the type A spermatogonium or the Sertoli cell. (Endocrinology 96: 564, 1975)

Footnotes

^* University of Washington, School of Medicine, Seattle, Washington.

Received March 15, 1974.

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