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Endocrinology, doi:10.1210/endo-96-3-781
Endocrinology Vol. 96, No. 3 781-786
Copyright © 1975 by the Endocrine Society.
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Inhibition by Iodide of the Activation of the Thyroid Cyclic 3',5'-AMP System

J. VAN SANDE, G. GRENIER, C. WILLEMS* and J. E. DUMONT

Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire (LMN) Faculté de Médecine, Université Libre de Bruxelles and Biology Department, Euratom Brussels, Belgium**

Abstract

The action of iodide on the cyclic AMP system of dog thryoid slices has been studied. Iodide inhibits the enhancement of cyclic AMP accumulation in the presence of TSH. Such an effect is also observed in horse, beef and sheep thyroid slices, but not in dog kidney slices stimulated by parathyroid hormone or in rat parotid slices stimulated by isoproterenol. The effect in dog thyroid slices is suppressed by iniM NaClO4, lm M methimazole and lmM propylthiouracil. Similar data have been obtained for prostaglandin Ei stimulation. Effects of thyrotropin mediated by cyclic AMP, i.e., activation of iodothyronine secretion, l-14C-glucose oxidation, and lactate formation, were also inhibited by iodide but not by iodide and methimazole. Similar activations when caused by dbcAMP were not inhibited by iodide. The data suggest a. model in which an intracellular agent resulting from the oxidation of iodide acts on the thyroid cyclic AMP system. (Endocrinology 96: 781, 1975)

Footnotes

* Boursier de Recherche Medicale du Quebec.

** Publication no. BIO 1013.

Received March 5, 1974.




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Copyright © 1975 by The Endocrine Society