This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Articles by MASIELLO, P. Articles by BERGAMINI, E. Search for Related Content PubMed PubMed Citation Articles by MASIELLO, P. Articles by BERGAMINI, E.

Age-Dependent Changes in the Sensitivity of the Rat to a Diabetogenic Agent (Streptozotocin)

Istituto di Patologia Generale dell'Universita di Pisa Italy

Abstract

Changes of plasma glucose levels have been investigated in rats of 50, 70, 90, 110 and 150 g BVV after the intravenous injection of 0, 40, 60, 80 or 100 mg/kg BW of streptozotocin.

The effect of streptozotocin was dependent on the dose used and on the size of the animals. With all animal sizes studied, a transient acute hyperglycemic response to streptozotocin was observed at doses lower than those required to produce persistent hyperglycemia. Smaller animals required higher doses of streptozotocin in order to produce changes comparable to those observed in larger animals. (Endocrinology 96: 787, 1975)

Received April 1, 1974.