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Compensatory Renal Hypertrophy in the Absence of Androgen Binding¹

Surgical Services, Massachusetts General Hospital and Shriners Burns Institute, Department of Surgery,Harvard Medical School Boston, Massachusetts 02114 Department of Biology, City of Hope Hospital Duarte, California 91010

Abstract

As a direct test for a role of androgens, compensatory renal hypertrophy was studied in normal male mice, in androgen-insensitive Tfm/Y mice, and in sibling normal female mice. Fifteen days after unilateral nephrectomy, although the kidneys of the normal male mice were larger, relative increases in renal weight were similar in all groups (33–43%). The magnitude of the increase and the contents of protein, RNA, and DNA were the same in the Tfm/Y mice and the female mice. Androgens are not essential to compensatory renal hypertrophy, but they promote larger mice with larger kidneys.(Endocrinology 96: 806, 1975)

Footnotes

¹ This work was supported by NIH Grants AM-12769 and NCI NO1CB33907.

² Address reprint requests to R. A. Malt, M.D., Massachusetts General Hospital, Boston, Massachusetts 02114.

Received July 15, 1974.