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Endocrinology, Vol 96, 1051-1054, Copyright © 1975 by Endocrine Society

ARTICLES

Synthesis of DNA in isolated pancreatic islets maintained in tissue culture

A Anderson

The DNA synthesis of isolated pancreatic islets has been determined after culture in vitro of the islets for 5 days in media containing either various glucose concentrations or tolbutamide or cortisone. Only glucose stimulated the replication of DNA, while cortisone was inhibitory and tolbutamide without effect. It is concluded that glucose by itself stimulates the mitotic rate of the islet cells and that the corresponding effect of steroids in vivo may be mediated through the ensuing hyperglycemia.


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B. Tyrberg, J. Ustinov, T. Otonkoski, and A. Andersson
Stimulated Endocrine Cell Proliferation and Differentiation in Transplanted Human Pancreatic Islets: Effects of the ob Gene and Compensatory Growth of the Implantation Organ
Diabetes, February 1, 2001; 50(2): 301 - 307.
[Abstract] [Full Text]


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Copyright © 1975 by The Endocrine Society