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Endocrinology, Vol 96, 1054-1058, Copyright © 1975 by Endocrine Society

ARTICLES

Catechol estrogen formation in the central nervous system of the rat

J Fishman and B Norton

Conversion of estradiol and estrone to catechol estrogens by rat hypothalamic tissue but not by the cerebral cortex was demonstrated from the incubation of these tissues with estradiol-2-3H and estrone-2- 3H and monitoring the incorporation of tritium into water. Direct evidence for this transformation was obtained by isolating the labelled phenazine derivative of 2-hydroxyestrone after hypothalamic incubation with estrone-4-14C.


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