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Endocrinology, Vol 96, 848-853, Copyright © 1975 by Endocrine Society
ARTICLES |
S Binkley, SE Macbride, DC Klein and CL Ralph
Pineal serotonin N-acetyltransferase activity and melatonin content exhibit marked daily rhythms in chickens; peak values occur during the period of low locomotor activity which coincides with dark in a 24-h light-dark regime. We studied the regulation of these daily rhythms by measuring pineal serotonin N-acetyltransferase activity, hydroxyindole- O-methyltransferase (HIOMT) activity, and melatonin content in experiments in which birds were exposed to light-to-dark and dark-to- light transitions at atypical times. We observed that there is a refractory period for dark-initiation of the increase in pineal N- acetyltransferase activity and melatonin content. We also learned that a dark-to-light transition causes a rapid decrease in dark-elevated pineal N-acetyltransferase activity and melatonin content. The rapid decrease occurs in blinded chickens as well as sighted ones. HIOMT activity did not change consistently in any of the experimental treatments.
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S Binkley, J. Riebman, and K. Reilly Timekeeping by the pineal gland Science, September 16, 1977; 197(4309): 1181 - 1183. [Abstract] [PDF]
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