help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Orr, E.
Right arrow Articles by Quay, W. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Orr, E.
Right arrow Articles by Quay, W. B.

Endocrinology, Vol 96, 941-945, Copyright © 1975 by Endocrine Society

ARTICLES

Hypothalamic 24-hour rhythms in histamine, histidine, decarboxylase and histamine-N-methyltransferase

E Orr and WB Quay

Twenty-four hour rhythms of histamine (H), its biosynthetic enzyme, L- histidine decarboxylase (EC 4.1.1.22, HD) and its inactivation enzyme, histamine N-methyltransferase (EC 2.1.1.8, HMT) were assayed in the 63- day-old male rat hypothalamus using a modified single isotopeenzyme microassay. H was found to have a 24-h rhythm with a maximum concentration at 11:00 h (lights on 10:00-22:00 h) and a minimum at 23:00 h. In vitro HD and HMT activities were also found to have 24-h rhythms with peak activites in both occurring at 04:00 h. HMT also had a broad secondary peak throughout the day, whereas HD activity during the day was dominated by a mid-light trough at 16:00 h. These rhythms are considered significant for evaluation of the control and physiological role of histamine in the mammalian hypothalamus.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
H. L. Haas, O. A. Sergeeva, and O. Selbach
Histamine in the Nervous System
Physiol Rev, July 1, 2008; 88(3): 1183 - 1241.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Parmentier, H. Ohtsu, Z. Djebbara-Hannas, J.-L. Valatx, T. Watanabe, and J.-S. Lin
Anatomical, Physiological, and Pharmacological Characteristics of Histidine Decarboxylase Knock-Out Mice: Evidence for the Role of Brain Histamine in Behavioral and Sleep-Wake Control
J. Neurosci., September 1, 2002; 22(17): 7695 - 7711.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Sallmen, A. L. Beckman, T. L. Stanton, K. S. Eriksson, J. Tarhanen, L. Tuomisto, and P. Panula
Major Changes in the Brain Histamine System of the Ground Squirrel Citellus lateralis during Hibernation
J. Neurosci., March 1, 1999; 19(5): 1824 - 1835.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1975 by The Endocrine Society