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Endocrinology, Vol 96, 1114-1118, Copyright © 1975 by Endocrine Society

ARTICLES

Pasma growth hormone responses to thyrotropin-releasing hormone in the urethane-anesthetized rat

Y Kato, K Chihara, K Maeda, S Ogo and Y Okanishi

Intravenous injection of synthetic thyrotropin-releasing hormone (TRH) resulted in a significant and dose-related increase in plasma growth hormone (GH) in the urethane anesthetized rat. The minimum effective does of TRH was 40 ng per 100 g body wt when administered intravenously. The maximum responses of plasma GH to TRH were observed at 5 min following TRH, whereas those of plasma TSH were obtained at 10 min. Pretreatment with either T3 (50 mug/100 g body wt ip) significantly suppressed both plasma GH and TSH responses to TRH. The GH release induced by TRH was significantly inhibited by somatostatin (5 mug/100 g body wt iv) which was injected 5 min and immediately before the injection of TRH.




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Copyright © 1975 by The Endocrine Society