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Endocrinology, Vol 96, 1145-1152, Copyright © 1975 by Endocrine Society

ARTICLES

Interaction of estrogen and gonadotrophins on follicular atresia

SM Harman, JP Louvet and GT Ross

We have investigated folluclar atresia by giving hypophysectomized immature female rats (HIFR) diethylstibestrol or gonadotrophins with and without the chemical antiestrogen CI-628, making total counts of normal and atretic follicles greater than 125 muM in diameter, and using a simple model to analyze data. Our results show an antiatretic effect of estrogen, independent of its well-documented mitogenic effect on preantral follicles. We have also shown that CI-628 acts as an anti- estrogen to block follicular proliferation, while acting as an estrogen to inhibit atresia. In addition, we have observed an increase in atresia caused by gonadotrophins, in opposition to their estrogen- mediated positive effect on follicular growth.


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