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Endocrinology, doi:10.1210/endo-96-6-1571
Endocrinology Vol. 96, No. 6 1571-1578
Copyright © 1975 by the Endocrine Society.
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Developmental Study of Androgen Responsiveness in the Submandibular Gland of the Mouse

JAMES F. DUNN and JEAN D. WILSON

Department of Internal Medicine, The University of Texas Southwestern Medical School Dallas, Texas 75235

Abstract

The development of androgen responsiveness in the submandibular gland of normal and androgen-resistant (Tfm) mice of different ages was studied after varying hormonal treatments. Total esteroproteolytic (tatnase) activity of submandibular gland homogenates was used as a marker for androgen action. Newborn mice of all four genotypes (normal male, normal female, carrier Tfm females, and Tfm males) were resistant to androgen. However, at 3 weeks of age the capacity to develop a tamase response appears in normal and carrier Tfm animals given androgen and rapidly rises to maximal levels. The level in the normal animal is regulated thereafter primarily by the level of circulating androgen. In contrast, the tamase response in the Tfm male of all ages and under all androgen regimens was minimal. (Endocrinology 96: 1571, 1975)

Received October 16, 1974.




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Copyright © 1975 by The Endocrine Society