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Endocrinology, Vol 97, 366-372, Copyright © 1975 by Endocrine Society

ARTICLES

Evidence of a role of adrogens in follicular maturation

JP Louvet, SM Harman, JR Schrieber and GT Ross

In hypophysectomized immature female rats (HIFR), the ovarian weight response to subcutaneously implanted diethylstilbestrol capsules (DESC) is inhibited by small doses of human chorionic gonadotropin (hCG). This effect, reproduced by equivalent doses of interstitial cell stimulating hormone (ICSH) but not by follicle-stimulating hormone (FSH), is inhibited by treatment with antiandrogens. These data implicate gonadotropic stimulation of interstitial cell androgen production in the control of follicular maturation in rats.




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Copyright © 1975 by The Endocrine Society