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Endocrinology, Vol 97, 475-478, Copyright © 1975 by Endocrine Society

ARTICLES

Relationship of steroid structure to induction of chymotrypsinogen in embryonic chick pancreas in vitro

A Cohen and RG Kulka

The effect of steroid structure on induction of chymotrypsinogen in embryonic chick pancreas was examined in vitro. In order of decreasing potency cortisol, corticosterone, and 21-deoxycortisol are classified as optimal inducers, whereas 11beta-hydroxyprogesterone, 11- deoxycortisol, cortisone, 11-deoxycorticosterone and 17-alpha- hydroxyprogesterone are classified as suboptimal inducers. Progesterone was inactive. It is concluded that the relative importance of the steroid hydroxyl groups for activity is 11beta greater than 21 greater than 17 alpha, and that their effect is cumulative.




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Copyright © 1975 by The Endocrine Society