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Endocrinology, Vol 97, 674-676, Copyright © 1975 by Endocrine Society

ARTICLES

Reversal by vasotocin of pinealectomy and constant light effects on the pituitary melanocyte-stimulating hormone (MSH) content in the mouse

S Pavel, C Gheorghiu, M Calb and M Petrescu

A single injection of 1 pg synthetic arginine vasotocin (AVT) into the third ventricle of the mouse completely prevented the pituitary MSH increase which occurs seven days after pinealectomy or 24 h after exposure to constant light. The same concentration of AVT injected into the third ventricle of normal mice markedly decreased the pituitary MSH content at 20 min following the injection. The present results suggest that AVT injected into the third ventricle of the mouse inhibits synthesis and/or release of MSH-release inhibiting factor (MIF).


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S. PAVEL, R. GOLDSTEIN, C. GHEORGHIU, and M. CALB
Pineal Vasotocin: Release into Cat Cerebrospinal Fluid by Melanocyte-Stimulating Hormone Release-Inhibiting Factor
Science, July 8, 1977; 197(4299): 179 - 180.
[Abstract] [PDF]


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Copyright © 1975 by The Endocrine Society