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Endocrinology, Vol 97, 1332-1335, Copyright © 1975 by Endocrine Society

ARTICLES

Thyroid state and brain monoamine metabolism

JH Jacoby, G Mueller and RJ Wurtman

The rates at which rat brain synthesizes catecholamines and serotonin were estimated by measuring the accumulation of DOPA and 5- hydroxytryptophan (5-HTP) 45 min after ip administration of the decarboxylase inhibitor RO4-4602 (800 mg/kg BW). Following thyroparathy- roidectomy, hypothyroid rats showed a decreased accumulation of both precursor amino acids. On the other hand, hyperthyroidism (caused by administering 15 mug T4/100 g BW for 25 days) accelerated the accumulation of catecholamines and serotonin. The accumulation of 5-HTP correlated closely with brain tryptophan concentration in all treatment groups; DOPA accumulation, however, did not similarly correspond to brain tyrosine levels.




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Copyright © 1975 by The Endocrine Society