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Endocrinology, Vol 97, 1336-1339, Copyright © 1975 by Endocrine Society

ARTICLES

The ACTH-releasing hormone of the hypothalamus requires a co-factor

AF Pearlmutter, E Rapino and M Saffran

Gel filtration of an extract of rat median eminence tissue in 0.1 N HCl on Sephadex G-25 separated two peaks, both with feeble ACTH-releasing activity. Full activity of the extract was regained when both peaks were recombined. This observation suggests that the ACTH-releasing hormone of the hypothalamus requires a co-factor for activity.


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M Lis, J Julesz, J Gutkowska, and J Genest
Corticotropin-releasing activity of alpha-melanotropin
Science, February 5, 1982; 215(4533): 675 - 677.
[Abstract] [PDF]


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Copyright © 1975 by The Endocrine Society