help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Walling, M. W.
Right arrow Articles by Kimberg, D. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Walling, M. W.
Right arrow Articles by Kimberg, D. V.

Endocrinology, Vol 97, 1567-1576, Copyright © 1975 by Endocrine Society

ARTICLES

Effects of 1alpha,25-dihydroxyvitamin D3 and Solanum glaucophyllum on intestinal calcium and phosphate transport and on plasma Ca, Mg and P levels in the rat

MW Walling and DV Kimberg

The responses elicited by a single dose of either S. glaucophyllum (SG) or 1alpha,25-dihydroxyvitamin D3 (1alpha, 25-(OH)2D3) in vitamin D- deficient rats were qualitatively identical. Both compounds stimulated duodenal absorption of calcium and phosphate 3 h after administration, and the effects persisted for 96 h. The SG effects on calcium transport were maximal at 6 h and exceeded the greatest response to 1alpha,25- (OH)2D3 which occurred at 48 h. While the early SG effects on phosphate absorption exceeded those of 1alpha,25-(OH)2D3, the latter compound had a much greater effect at 48 h. Both SG and 1alpha, 25-(OH)2D3 produced marked hyperphosphatemia that was accompanied by hypocalcemia and transient hypermagnesemia at 3-6 h. The phosphatemia increased for 48 h in the 1alpha,25-(OH)2D3 group and fell toward baseline between 48 and 96 h, while this parameter was maximal in the SG group at 3-12 h and returned to baseline values by 96 h. Plasma calcium levels tended to vary inversely with phosphorus concentrations and did not exceed baseline values until 48 h for the SG group and 96 h for the 1alpha,25- (OH)2D3 group. We suggest that the hypocalcemia is due to calcium phosphate precipitation. The quantitative differences in the effects on calcium and phosphorus metabolism may be dose-related. The responses to SG suggest that a gram of dried leaf has approximately the same activity as 1 mug of 1alpha,25-(OH)2D3. It appears that the water- soluble SG factor has the same biological effects on Ca and P metabolism as does 1alpha,25-(OH)2D3.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
H. Segawa, I. Kaneko, S. Yamanaka, M. Ito, M. Kuwahata, Y. Inoue, S. Kato, and K.-i. Miyamoto
Intestinal Na-Pi cotransporter adaptation to dietary Pi content in vitamin D receptor null mice
Am J Physiol Renal Physiol, July 1, 2004; 287(1): F39 - F47.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. Wasserman, J. Henion, M. Haussler, and T. McCain
Calcinogenic factor in Solanum malacoxylon: evidence that it is 1,25-dihydroxyvitamin D3-glycoside
Science, November 19, 1976; 194(4267): 853 - 855.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Xu, L. Bai, J. F. Collins, and F. K. Ghishan
Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)2 vitamin D3
Am J Physiol Cell Physiol, March 1, 2002; 282(3): C487 - C493.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1975 by The Endocrine Society