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Endocrinology, doi:10.1210/endo-98-1-139
Endocrinology Vol. 98, No. 1 139-145
Copyright © 1976 by the Endocrine Society.
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Serum Growth Hormone and Prolactin During and After the Development of the Obese-Hyperglycemic Syndrome in Mice

B. A. LARSON1, Y. N. SINHA and W. P. VANDERLAAN

Division of Diabetes and Endocrinology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Supported by Grant CA-14025 from NCI and by an award from the Kroc Foundation.

Abstract

Mice with the recessively inherited obese-hyperglycemic syndrome (ob/ob) and their nonobese litter mates were studied over a 26-week period. The body weights and serum glucose levels of ob/ob mice began to rise markedly at 5–6 weeks of age and remained elevated throughout the period of study. Obese mice were significantly heavier (P < .001) and had higher serum glucose levels (P < .001) than lean mice, but obese mice had variably lower serum growth hormone (GH) and prolactin (PRL) levels (P < .001) than lean litter mate controls after 4–5 weeks of life. A 24 h rhythm study performed on 15-week-old mice revealed a relatively unaltered but attenuated pattern of GH and PRL secretion in ob/ob mice. During and after the development of the obese-hyperglycemic syndrome, thelow levels of these two hormones probably indicates an altered hypothalamic regulation of pituitary function.(Endocrinology 98: 139, 1976)

Footnotes

1 Present-address: Center for Endocrinology, Metabolism, and Nutrition, Northwestern University Medical School, Chicago, Illinois 60611.

Received April 9, 1975.




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Copyright © 1976 by The Endocrine Society