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Endocrinology Vol. 138, No. 10 4489-4492
Copyright © 1997 by The Endocrine Society

ARTICLES

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

Clement C. Cheung, Donald K. Clifton and Robert A. Steiner

Departments of Obstetrics & Gynecology, Box 356460 (R.A.S., D.K.C.), Physiology & Biophysics, Box 357290, (C.C.C., R.A.S.), and Zoology (R.A.S.), University of Washington, Seattle Washington 98195

Address all correspondence and requests for reprints to: Robert A. Steiner, Ph.D., University of Washington, Department of Physiology & Biophysics, Box 357290, Seattle, Washington 98195.


   Abstract
Top
 Abstract
 
Leptin is a protein product of the obese (ob) gene, which is secreted by adipocytes and functions as a satiety factor to regulate food intake. The expression of the leptin receptor in several hypothalamic nuclei suggests that multiple neuronal subtypes are targets for leptin’s action. Products of the proopiomelanocortin (POMC) gene are known to affect feeding behavior, and POMC neurons share a similar distribution with leptin receptor mRNA in the arcuate nucleus. We used double label in situ hybridization and computerized image analysis to test the hypothesis that POMC neurons coexpress the leptin receptor. Quantitative analysis confirmed that POMC neurons in the hypothalamus express leptin receptor mRNA. Based on this observation, we infer that POMC neurons and the products of the POMC gene may be part of the signaling pathway mediating leptin’s action on feeding and perhaps other physiological functions.

Received May 5, 1997.




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