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Endocrinology Vol. 138, No. 12 5649-5652
Copyright © 1997 by The Endocrine Society

ARTICLES

The Distribution of Estrogen Receptor-ß mRNA in Forebrain Regions of the Estrogen Receptor-{alpha} Knockout Mouse

Paul Shughrue, Paul Scrimo, Malcolm Lane, Roger Askew and Istvan Merchenthaler

The Women’s Health Research Institute (P.S., P.S., M.L., I.M.), Wyeth-Ayerst Research, Radnor, Pennsylvania 19087; and Molecular Genetics (R.A.), Wyeth-Ayerst Research, Princeton, New Jersey 08543

Address all correspondence and requests for reprints to: Paul J. Shughrue, Ph.D., Wyeth-Ayerst Research, 145 King of Prussia Road, Radnor, Pennsylvania 19087.


   Abstract
Top
 Abstract
 
Neurons in the hypothalamus of estrogen receptor {alpha}-knockout (ER{alpha}KO) mice have been shown to concentrate radiolabeled estrogen and estrogen treatment regulates the expression of progesterone receptor mRNA. The purpose of the present study was to utilize in situhybridization histochemistry to determine the anatomical distribution of ERß mRNA in ER{alpha}KO mouse forebrain. The results of these studies revealed an extensive distribution of ERß mRNA in the hypothalamic regions including medial preoptic area, suprachiasmatic nucleus, paraventricular nucleus, dorsomedial nucleus, medial tuberal nucleus, and the premammillary nuclei. Additional labeled perikarya were also detected in the glomerular layer of the olfactory bulb; tenia tecta; anterior septum; bed nucleus of the stria terminalis; medial, basolateral and cortical nuclei of the amygdala; cerebral and entorhinal cortex; the septohippocampal nucleus; Ammon’s horn of the hippocampus and the dorsal raphe. The results of these in situhybridization histochemical studies have provided novel information about the distribution of ERß mRNA in the ER{alpha}KO mouse forebrain. In addition, these morphological data provides evidence that estrogen may exert its actions in the ER{alpha}KO mouse brain via ERß and thereby maintain organizational and activational effects.

Received September 5, 1997.




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This Article
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