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A Proliferative Effect of Transforming Growth Factor-ß1 on a Human Prostate Cancer Cell Line, TSU-Pr1

Department of Urology, Northwestern University Medical School, Chicago, Illinois 60611

Address all correspondence and requests for reprints to: Chung Lee, Department of Urology, Northwestern University, Chicago, Illinois 60611.

	Abstract

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Transforming growth factor-ß (TGF-ß) is growth inhibitory to many malignant cells, including prostate cancer cells. The present study reports an unusual observation in that TGF-ß is growth stimulatory to a human prostate cancer cell line, TSU-Pr1. The TSU-Pr1 line is highly aggressive and exhibits a rapid rate of proliferation in culture. These cells underwent further proliferation in response to TGF-ß1. Both type I and II receptors to TGF-ß (TßR-I, TßR-II) are expressed in TSU-Pr1 cells. Activation of a luciferase reporter gene, which contains a TGF-ß response element, confirmed that the TGF-ß receptors in TSU-Pr1 cells were functional. RT-PCR analysis and an ELISA assay determined that TSU-Pr1 cells secreted TGF-ß. In conclusion, TSU-Pr1 cells contain functional TGF-ß receptors but instead of the usual growth inhibition by TGF-ß1, these cells undergo proliferation. The present observation provides a proliferative role of TGF-ß in TSU-Pr1 cells, which may play a part in the aggressive phenotype of these cells and, perhaps other prostate cancer cells.

Received October 7, 1997.

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This Article Abstract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lamm, M. L. G. Articles by Lee, C. Search for Related Content PubMed PubMed Citation Articles by Lamm, M. L. G. Articles by Lee, C.