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Endocrinology Vol. 139, No. 6 3022-3025
Copyright © 1998 by The Endocrine Society

ARTICLES

Mice Lacking the Type I Interleukin-1 Receptor Do Not Lose Bone Mass after Ovariectomy

Joseph A. Lorenzo, Anica Naprta, Yue Rao, Cynthia Alander, Moira Glaccum, Michael Widmer, Gloria Gronowicz, Judith Kalinowski and Carol C. Pilbeam

VA Connecticut Healthcare System (J.A.L., J.K.), Newington, Connecticut 06111; The Departments of Medicine (Y.R., C.A., C.C.P.) and Orthopedics (A.N., G.G.), University of Connecticut Health Center, Farmington, Connecticut 06030; and Immunex Research and Development Corporation (M.G., M.W.), Seattle, Washington 98101

Address all correspondence and requests for reprints to: Joseph Lorenzo, M.D., VA Connecticut Healthcare System, 555 Willard Avenue, Building 5, Research, Newington, Connecticut 06111.


   Abstract
Top
 Abstract
 
We measured the effects of ovariectomy on the bone mass of mice that lacked type I interleukin-1 receptor (IL-1 R1 -/- mice) in two genetic backgrounds (C57BL/6 x 129/Sv and C57BL/6) to investigate the role of interleukin-1 in the actions of estrogen on bone. At three weeks after surgery, ovariectomized wild-type mice decreased trabecular bone volume in the proximal humerus by 70% in a C57BL/6 x 129/Sv background and 48% in a C57BL/6 background compared to sham-operated controls. In contrast, there was no significant decrease in trabecular bone mass in IL-1 R1 -/- mice after ovariectomy. The estrogen status of all groups was confirmed by measurement of uterine wet weight. These results demonstrate that a functional IL-1 response pathway is required for mice to lose trabecular bone mass after ovariectomy in this model and they imply that IL-1 is an important mediator of the effects of ovariectomy on bone mass. Hence, therapeutic interventions that block the effects of IL-1 on bone may be beneficial for treating diseases of rapid bone loss such as post-menopausal osteoporosis.

Received January 28, 1998.




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