Endocrinology Vol. 141, No. 10 3916-3919
Copyright © 2000 by The Endocrine Society
Is the Early Increase in Leptinemia One of the Anorectic Signals Induced by an Essential Amino Acid-Deficient Diet in the Rat?
Sebastien Feurté,
Stylianos Nicolaïdis and
Kyriaki Gerozissis
Address all correspondence and requests for reprints to: Sebastien Fuerté, CNRS ESA, 2 place Jussieu, Physiopathologie de la Nutrition, Paris Cedex 05, 75251 France. E-mail:
gerozi{at}paris7.jussieu.fr
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Abstract
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Rats start decreasing their food intake as early as 70 min after the
first ingestion of a food deficient in threonine. A decrease of the
limiting essential amino acid (EAA) in the plasma was proposed to be
the first anorectic signal. Because many hormones regulate feeding
behavior, we studied the effect of a meal (46 kJ) that was either
devoid of threonine or was corrected for the deficiency, on plasma
leptin, insulin and glucagon levels using a radio-immunoassay, at 0 to
180 min after the meal. One hour after ingestion of the
threonine-devoid meal, a larger increase in insulinemia (22±1 vs.
15±1 µU/ml) and leptinemia (7.8±0.5 vs. 4.4±0.6 ng/ml;
p<0.001) was observed than after ingestion of the corrected
meal. The area under the curve of the threonine-devoid meal group was 3
and 1.34 fold larger than for the corrected meal group for insulin and
leptin respectively. Glucagonemia was not different between the two
groups. We propose that the rise in leptinemia, perhaps in synergy with
rise in plasma insulin, might serve as one early signal to brain
structures, participating in the anorectic mechanism following
ingestion of an EAA-deficient diet.
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Introduction
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Received February 10, 2000.
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Abstract
Introduction
