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Monash Institute of Reproduction and Development (K.L.J., J.N.B., D.M.deK., D.J.P.), Monash University, Clayton, Victoria 3168, Australia, and Oxford Brookes University (N.P.G.), Oxford, United Kingdom
Address all correspondence and requests for reprints to: David J. Phillips, Monash Institute of Reproduction and Development, Monash Medical Center, 246 Clayton Road, Clayton, Australia 3168.
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 Top Abstract |
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Recent evidence suggests a role for activin A, and its binding protein,
follistatin, in inflammatory pathways. However, whether activin is
released systemically during inflammation is not known. In this study,
a release of activin A into the circulation occurred in sheep within 1
hour of injection of lipopolysaccharide. This rapid peak in activin A
preceded the release of the key inflammatory cytokines, tumor necrosis
factor-
and interleukin-6. Follistatin release into the circulation
occurred some 4 hours after the peak of activin A and continued out to
24 hours from lipopolysaccharide treatment. These data are the first to
document a circulatory response of activin A to an inflammatory
stimulus, and together with previous findings, suggest that activin A
may have both pro- and anti-inflammatory actions in regulating
cytokine-driven pathways.
Received December 28, 1999.
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