Correction
for Maeda and Tsukamura, Endocrinology 147 (3) 1085-1086.
Endocrinology Vol. 147, No. 5 2505
Copyright © 2006 by The Endocrine Society
Erratum
In the News & Views article "The impact of stress on reproduction: are glucocorticoids inhibitory or protective to gonadotropin secretion?" by K.-I. Maeda and H. Tsukamura (Endocrinology 147:1085–1086, 2006) and the paper discussed in the article (1), there were several unintentional omissions of related studies on the stimulatory effect of glucocorticoids on stress-induced gonadotropin secretion in female rats. In the 1970s several labs reported that reduction of glucocorticoid secretion during stress in male or male and female (2, 3) rats further inhibited the HPG system and that replacement with glucocorticoids had a positive effect, leading to the conclusion that central components of the HPA system were responsible for the stress-induced inhibition of the gonadal system. Subsequent study of the phenomenon (4) confirmed the early results in male rats. However, no mechanisms for the effect were elucidated. It is a pleasure that, with time, mechanisms that potentially mediate these long-observed endocrine effects can be found and that the current results (1) validate the conclusions of these earlier studies.
References
- Matsuwaki T, Kayasuga Y, Yamanouchi K, Nishihara M 2006 Maintenance of gonadotropin secretion under stress conditions through the inhibition of prostaglandin synthesis in the brain. Endocrinology 147:1087–1093[Abstract/Free Full Text]
- Gray GD, Smith ER, Damassa DA, Ehrenkranz JR, Davidson JM 1978 Neuroendocrine mechanisms mediating the suppression of circulating testosterone levels associated with chronic stress in male rats. Neuroendocrinology 25:247–256[Medline]
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