Correction
for Greeley, Endocrinology 149 (6) 3184-3186.
Correction
for Howarth et al., Endocrinology 149 (5) 2411-2422.
Endocrinology Vol. 149, No. 10 5315
Copyright © 2008 by The Endocrine Society
Erratum
In the News & Views article "Evidence for Intelligent Design in Gastrointestinal Endocrinology: Identification of novel cholecystokinin/gastrin-like peptides in the nematode Caenorhabditis elegans" (Endocrinology 149:3184–3186, 2008), the title of the article should have read "Evidence for Ingenious Design in Gastrointestinal Endocrinology: Identification of novel cholecystokinin/gastrin-like peptides in the nematode Caenorhabditis elegans." The editors regret this error, which may have given the title an unintended meaning.
In the article "Paralogous Vitamin D Receptors in Teleosts: Transition of Nuclear Receptor Function" by Deanna L. Howarth, Sheran H. W. Law, Benjamin Barnes, Julie M. Hall, David E. Hinton, Linda Moore, Jodi M. Maglich, John T. Moore, and Seth W. Kullman (<Endocrinology 149:2411–2422), the authors recently identified an experimental error in their manuscript. The authors initially reported (Figures 5 and 6) that transactivational activity of medaka VDR
was significantly attenuated in comparison to paralogous medaka VDRβ. In subsequent studies the authors in fact demonstrated that VDR exhibits greater activity than medaka VDRβ with the prototypic substrate 1,25(OH)2D3. In the figure below the authors additionally demonstrate that differential activities between teleosts VDR and VDRβ paralogs are consistent across several species including medaka, zebrafish and Tetraodon. The authors regret the error and any potentially misleading information to the readers. (They stand by their hypothesis that differential activities between VDR paralogs are due to subfunctional and/or neofunctionalization events that occurred subsequent to the fish specific whole genome duplication event).
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FIG. 1. Legend: Transfections were conducted as described in original manuscript using constructs containing the complete open reading frame for each teleost VDR gene (mVDR-medaka, zfVDR-zebrafish, tetVDR-Tetraodon) in the pSG5 expression plasmid, human CYP3A (XREM-Luc) reporter construct, and Renilla luciferase (pRL-CMV, Promega) with 12 nM 1,25(OH)2D3 (black bars) or vehicle only (white bars). All assays were conducted in triplicate in HepG2 cells as described in materials and methods.
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