Supplemental Data

Supplemental Data

Files in this Data Supplement:

• Supplemental Figure S1 - Mean T4 and TSH activity (cAMP) in wild type, E7 and RP3 mouse sera.
• Supplemental Figure S2 - Expression ratios of some cell cycle related-gene in E7 and RP3 thyroids of 2, 6 and 10 month old mice.
• Supplemental Figure S3 - Statistical significance of the 3 most represented biological processes (GO level 4) among the upregulated genes from Delys et al. microarray data on human PTC following analysis with DAVID software; Benjamini-Hochberg FDR (false discovery rate) < or = 0.05.
• Supplemental Figure S4 - Statistical significance of the 2 most represented pathways among upregulated genes from Delys et al. microarray data on human PTC following analysis with DAVID software; Benjamini-Hochberg FDR (false discovery rate) < or = 0.05.
• Supplemental Figure S5 - Statistical significance of the 8 most represented biological processes (GO level 4) among E7 6 month upregulated genes following analysis with DAVID software; Benjamini-Hochberg FDR (false discovery rate) < or = 0.05.
• Supplemental Figure S6 - mRNA expression level calculated by real-time PCR (SYBR Green) of 11 genes regulated in microarray data; comparison of gene expression level in wt, RP3 and E7 thyroids; statistical analysis was performed with a two-way ANOVA test.
• Supplemental Figure S7 - Gene-specific primers used for the real-time PCR experiments (11 target genes and 6 housekeeping genes).