Supplemental Data

Supplemental Data

Files in this Data Supplement:

• Supplemental Table 1 - Primer sequences used for real-time PCR
• Supplemental Table 2 - Acrophase of mRNA expression of clock and adiponectin signaling pathway components
• Supplemental Figure 1 - The effect of fasting and high-fat diet on the phase of circadian expression.
  Under fasting, low levels of adenosine monophosphate (AMP) activate the expression of AMP-activated protein kinase (AMPK) leading to the phosphorylation of casein kinase I epsilon (CKIε). Phosphorylated CKIε leads to the degradation of PER proteins generating a phase advance (47). High-fat diet lowers the levels of activated AMPK, CKIε remains in the hypo-phosphorylated state and the half-life of the PER proteins increases, which leads to a phase delay.