Up-Regulation of ₅-Integrin by E-Cadherin Loss in Hypoxia and Its Key Role in the Migration of Extravillous Trophoblast Cells during Early Implantation

Supplemental Data

Supplemental Data

Files in this Data Supplement:

• Supplemental Figure S1 - Serial cross-sections of placental bed tissues obtained from a patient at 32 weeks of gestation. Decidua (lower) and myometrium (upper) are shown. A and F, H&E staining. B and G, the section was immunostained with cytokeratin-7 to visualize cytotrophoblasts. Immunolocalization of E-cadherin (C and H), α₅-integrin (D and I), and phospho-FAK (Tyr⁸⁶¹) (E and J) is shown. Representative pictures are shown at low (x40, upper) and high (x200, lower) magnification. Bar, 50 μm.
• Supplemental Figure S2 - Serial cross-sections of placental bed tissues obtained from a patient with preeclampsia at 28 weeks of gestation. Decidua (lower) and myometrium (upper) are shown. A and D, H&E staining. B and E, the section was immunostained with cytokeratin-7 to visualize cytotrophoblasts. C and F, immnolocalization of E-cadherin. Representative pictures are shown at low (x40, upper) and high (x200, lower) magnification. Bar, 50 μm