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Endocrinology Vol. 142, No. 10 4568-4571
Copyright © 2001 by The Endocrine Society

ARTICLES

Grtp1, A Novel Gene Regulated by Growth Hormone

Chunxia Lu, John Kasik, Dietrich A. Stephan, Shaohua Yang, Mark A. Sperling and Ram K. Menon

Department of Pediatrics, Children’s Hospital of Pittsburgh (C.L., J.K., S.Y., M.A.S., R.K.M.), Pittsburgh, Pennsylvania 15213; and Research Center for Genetic Medicine, Children’s National Medical Center (D.A.S.), Washington D.C. 20010

An in vitro model of GH-responsive cells was subjected to microarray analysis to identify a novel gene regulated by GH. This 258 amino acid protein, we term GH Regulated TBC Protein-1 (GRTP1), contains the TBC signature motif of GTPase activator proteins of Rab-like small GTPases. Northern blot analysis revealed a 1.3 kb major mRNA species, most abundant in testes. TaqMan assay confirmed that in the mouse, Grtp1 is expressed at highest levels in testes, with lesser abundance in intestine, kidney, lung, and liver. In the testis, expression of Grtp1 significantly increases post-pubertally. Administration of GH to mice increased levels of GRTP1 mRNA in testes (140%), but decreased GRTP1 mRNA abundance in kidney (50%) and liver (25%). Grtp1 was localized to mouse proximal chromosome 8. Orthologs of this protein are present in human, mouse, rat, and drosophila suggesting that GRTP1 has an important biological role(s).




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Copyright © 2001 by The Endocrine Society