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Endocrinology, doi:10.1210/en.2003-0536
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Endocrinology Vol. 144, No. 11 4729-4733
Copyright © 2003 by The Endocrine Society

BRIEF COMMUNICATION

A Role for Neuropeptide W in the Regulation of Feeding Behavior

Muhtashan S. Mondal, Hideki Yamaguchi, Yukari Date, Takuya Shimbara, Koji Toshinai, Yukio Shimomura, Masaaki Mori and Masamitsu Nakazato

Department of Internal Medicine, Miyazaki Medical College (M.S.M., H.Y., Y.D., T.S., K.T., M.N.), Miyazaki 889-1692, Japan; and Discovery Research Laboratories, Pharmaceuticals Research Division, Takeda Chemical Industries Ltd. (Y.S., M.M.), Ibaraki 300-4293, Japan

Address all correspondence and requests for reprints to: Masamitsu Nakazato, M.D., Ph.D., Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889-1692, Japan. E-mail: nakazato{at}post.miyazaki-med.ac.jp.

Abstract

Neuropeptide W (NPW) is a novel hypothalamic peptide that activates the previously described orphan G protein-coupled receptors, GPR7 and GPR8. Two endogenous molecular forms of NPW that consist of 23- and 30-amino acid residues were identified. The localization of GPR7 and GPR8 in some hypothalamic regions of primary importance in the regulation of feeding behavior has provided a springboard for investigation of the role of NPW in the central nervous system. In this study we examined the effects of NPW on feeding and energy expenditure in rats. Single intracerebroventricular (icv) administration of NPW23 and NPW30 to free-feeding rats suppressed dark phase and fasting-induced food intake at similar effective doses. Continuous icv infusion of NPW using an osmotic minipump suppressed feeding and body weight gain over the infusion period. Conversely, icv administration of anti-NPW IgG stimulated feeding. Furthermore, icv administration of NPW increased body temperature and heat production. These data raise the possibility that NPW functions as an endogenous catabolic signaling molecule in the brain. Further investigation of the biochemical and physiological functions of NPW will help us to better understand the hypothalamic regulation of energy homeostasis.




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