| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Endocrine Unit, Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London. W12 0NN, United Kingdom
Address all correspondence and requests for reprints to: Professor Stephen Bloom, Endocrine Unit, Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom. E-mail: s.bloom{at}imperial.ac.uk.
Oxyntomodulin (OXM) is a circulating gut hormone released post prandially from cells of the gastrointestinal mucosa. Given intracerebroventricularly to rats, it inhibits food intake and promotes weight loss. Here we report that peripheral (ip) administration of OXM dose-dependently inhibited both fast-induced and dark-phase food intake without delaying gastric emptying. Peripheral OXM administration also inhibited fasting plasma ghrelin. In addition, there was a significant increase in c-fos immunoreactivity, a marker of neuronal activation, in the arcuate nucleus (ARC). OXM injected directly into the ARC caused a potent and sustained reduction in refeeding after a fast. The anorectic actions of ip OXM were blocked by prior intra-ARC administration of the glucagon-like peptide-1 (GLP-1) receptor antagonist, exendin9–39, suggesting that the ARC, lacking a complete blood-brain barrier, could be a potential site of action for circulating OXM. The actions of ip GLP-1, however, were not blocked by prior intra-ARC administration of exendin9–39, indicating the potential existence of different OXM and GLP-1 pathways. Seven-day ip administration of OXM caused a reduction in the rate of body weight gain and adiposity. Circulating OXM may have a role in the regulation of food intake and body weight.
This article has been cited by other articles:
 |
|
 |
|
  W. Kim and J. M. Egan The Role of Incretins in Glucose Homeostasis and Diabetes Treatment Pharmacol. Rev., December 1, 2008; 60(4): 470 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Maida, J. A. Lovshin, L. L. Baggio, and D. J. Drucker The Glucagon-Like Peptide-1 Receptor Agonist Oxyntomodulin Enhances {beta}-Cell Function but Does Not Inhibit Gastric Emptying in Mice Endocrinology, November 1, 2008; 149(11): 5670 - 5678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Bloom, F. P. Kuhajda, I. Laher, X. Pi-Sunyer, G. V. Ronnett, T. M.M. Tan, and D. S. Weigle The Obesity Epidemic: Pharmacological Challenges Mol. Interv., April 1, 2008; 8(2): 82 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. C. Parkinson, W. S. Dhillo, C. J. Small, O. B. Chaudhri, G. A. Bewick, I. Pritchard, S. Moore, M. A. Ghatei, and S. R. Bloom PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones Am J Physiol Endocrinol Metab, April 1, 2008; 294(4): E698 - E708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. B. Chaudhri, K. Wynne, and S. R. Bloom Can Gut Hormones Control Appetite and Prevent Obesity? Diabetes Care, February 1, 2008; 31(Supplement_2): S284 - S289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Parlevliet, A. C. Heijboer, J. P. Schroder-van der Elst, L. M. Havekes, J. A. Romijn, H. Pijl, and E. P. M. Corssmit Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E142 - E147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-T. Kuo, J. R. C. Parkinson, O. B. Chaudhri, A. H. Herlihy, P.-W. So, W. S. Dhillo, C. J. Small, S. R. Bloom, and J. D. Bell The Temporal Sequence of Gut Peptide CNS Interactions Tracked In Vivo by Magnetic Resonance Imaging J. Neurosci., November 7, 2007; 27(45): 12341 - 12348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. M. Smeets, S. Vidarsdottir, C. de Graaf, A. Stafleu, M. J. P. van Osch, M. A. Viergever, H. Pijl, and J. van der Grond Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E754 - E758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Jorgensen, V. Kubale, M. Vrecl, T. W. Schwartz, and C. E. Elling Oxyntomodulin Differentially Affects Glucagon-Like Peptide-1 Receptor beta-Arrestin Recruitment and Signaling through G{alpha} J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 148 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Sowden, D. J. Drucker, D. Weinshenker, and S. J. Swoap Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R962 - R970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. G. Murphy, W. S. Dhillo, and S. R. Bloom Gut Peptides in the Regulation of Food Intake and Energy Homeostasis Endocr. Rev., December 1, 2006; 27(7): 719 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Gosman, H. I. Katcher, and R. S. Legro Obesity and the role of gut and adipose hormones in female reproduction Hum. Reprod. Update, September 1, 2006; 12(5): 585 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Druce and S R Bloom The regulation of appetite Arch. Dis. Child., February 1, 2006; 91(2): 183 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Young Obesity: A Peptide YY-Deficient, But Not Peptide YY- Resistant, State Endocrinology, January 1, 2006; 147(1): 1 - 2. [Full Text] [PDF]
|
|
|
|
|
|
N. M. Neary, C. J. Small, M. R. Druce, A. J. Park, S. M. Ellis, N. M. Semjonous, C. L. Dakin, K. Filipsson, F. Wang, A. S. Kent, et al. Peptide YY3-36 and Glucagon-Like Peptide-17-36 Inhibit Food Intake Additively Endocrinology, December 1, 2005; 146(12): 5120 - 5127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Vessey, D. A. Rushforth, and W. K. Stell Glucagon- and Secretin-Related Peptides Differentially Alter Ocular Growth and the Development of Form-Deprivation Myopia in Chicks Invest. Ophthalmol. Vis. Sci., November 1, 2005; 46(11): 3932 - 3942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Stanley, K. Wynne, B. McGowan, and S. Bloom Hormonal Regulation of Food Intake Physiol Rev, October 1, 2005; 85(4): 1131 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Talsania, Y. Anini, S. Siu, D. J. Drucker, and P. L. Brubaker Peripheral Exendin-4 and Peptide YY3-36 Synergistically Reduce Food Intake through Different Mechanisms in Mice Endocrinology, September 1, 2005; 146(9): 3748 - 3756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Wynne, A. J. Park, C. J. Small, M. Patterson, S. M. Ellis, K. G. Murphy, A. M. Wren, G. S. Frost, K. Meeran, M. A. Ghatei, et al. Subcutaneous Oxyntomodulin Reduces Body Weight in Overweight and Obese Subjects: A Double-Blind, Randomized, Controlled Trial Diabetes, August 1, 2005; 54(8): 2390 - 2395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Badman and J. S. Flier The Gut and Energy Balance: Visceral Allies in the Obesity Wars Science, March 25, 2005; 307(5717): 1909 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Wynne, S. Stanley, B. McGowan, and S. Bloom Appetite control J. Endocrinol., February 1, 2005; 184(2): 291 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.G. Murphy and S.R. Bloom Gut hormones in the control of appetite Exp Physiol, September 1, 2004; 89(5): 507 - 516. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
