| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Address all correspondence and requests for reprints to: Dr. S. Bi, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, Maryland 21205. E-mail: sbi{at}jhmi.edu.
Otsuka Long-Evans Tokushima fatty (OLETF) rats lacking cholecystokinin-A receptors are hyperphagic, obese, and diabetic. Although exercise attenuates OLETF rats’ obesity, the mechanisms underlying the effects of exercise are unclear. In this study, we determined the effects of running wheel activity on patterns of body weight gain, food intake, and hypothalamic gene expression. We demonstrate that voluntary running activity beginning at 8 wk of age normalized meal patterns, food intake, body weight, and plasma levels of glucose and leptin in OLETF rats. During the initial exercise period, corticotropin-releasing factor (CRF) mRNA expression was significantly elevated in the dorsomedial hypothalamus (DMH) but not in the paraventricular nucleus in both OLETF and control Long-Evans Tokushima rats. In response to long-term exercise, arcuate nucleus (Arc) neuropeptide Y (NPY), and proopiomelanocortin as well as DMH NPY and CRF mRNA expression were increased in Long-Evans Tokushima rats. In contrast, whereas exercising OLETF rats had increased Arc NPY and DMH CRF expression, Arc proopiomelanocortin and DMH NPY mRNA levels were not elevated. Finally, we demonstrate that the effects of exercise on body weight in OLETF rats were long lasting. Although food intake and body weight were increased in OLETF rats when running wheels were locked, weights did not return to those of sedentary OLETF rats. Together, these data suggest that the elevation of DMH CRF expression may mediate the short-term feeding inhibitory effects of exercise and that exercise limits the elevation of DMH NPY expression to account for the overall prevention of OLETF rats’ obesity.
This article has been cited by other articles:
 |
|
 |
|
  L. Yang, K. A. Scott, J. Hyun, K. L. Tamashiro, N. Tray, T. H. Moran, and S. Bi Role of Dorsomedial Hypothalamic Neuropeptide Y in Modulating Food Intake and Energy Balance J. Neurosci., January 7, 2009; 29(1): 179 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Rector, J. P. Thyfault, M. J. Laye, R. T. Morris, S. J. Borengasser, G. M. Uptergrove, M. V. Chakravarthy, F. W. Booth, and J. A. Ibdah Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats J. Physiol., September 1, 2008; 586(17): 4241 - 4249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Morris, M. J. Laye, S. J. Lees, R. S. Rector, J. P. Thyfault, and F. W. Booth Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat J Appl Physiol, March 1, 2008; 104(3): 708 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Rector, J. P. Thyfault, R. T. Morris, M. J. Laye, S. J. Borengasser, F. W. Booth, and J. A. Ibdah Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats Am J Physiol Gastrointest Liver Physiol, March 1, 2008; 294(3): G619 - G626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-M. Lo, L. C. Samuelson, J. B. Chambers, A. King, J. Heiman, R. J. Jandacek, R. R. Sakai, S. C. Benoit, H. E. Raybould, S. C. Woods, et al. Characterization of mice lacking the gene for cholecystokinin Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R803 - R810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Patterson, A. A. Dunn-Meynell, and B. E. Levin Three weeks of early-onset exercise prolongs obesity resistance in DIO rats after exercise cessation Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R290 - R301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Kotz Rewired to be thin? When exercise hits the brain Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R288 - R289. [Full Text] [PDF]
|
|
|
|
|
|
F. Zammaretti, G. Panzica, and C. Eva Sex-dependent regulation of hypothalamic neuropeptide Y-Y1 receptor gene expression in moderate/high fat, high-energy diet-fed mice J. Physiol., September 1, 2007; 583(2): 445 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Aja, S. Bi, S. B. Knipp, J. M. McFadden, G. V. Ronnett, F. P. Kuhajda, and T. H. Moran Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R148 - R154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kuramochi, T. Onaka, D. Kohno, S. Kato, and T. Yada Galanin-Like Peptide Stimulates Food Intake via Activation of Neuropeptide Y Neurons in the Hypothalamic Dorsomedial Nucleus of the Rat Endocrinology, April 1, 2006; 147(4): 1744 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hajnal, M. Covasa, and N. T. Bello Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1675 - R1686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Levin and C. M. Patterson Exercising the Obese Brain: Resetting the Defended Body Weight Endocrinology, April 1, 2005; 146(4): 1674 - 1675. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
