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Submitted on October 27, 2003
Accepted on December 23, 2003
Department of Biochemistry, Faculty of Medicine, Mie University, 2-174 Edobashi, Tsu, Mie 514-8507, Japan; Department of Exercise Biochemistry, Insititute of Health and Sports Science, Tsukuba University, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574, Japan; Department of Psychiatry, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, Ohio 45267-0559, USA; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Ave., New York, NY 10021-6399, USA; Department of Clinical Nutrition, Faculty of Health and Hygiene, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan; Faculty of Human Health Science, Tokai Gakuen University, 2-901 Nakahira, Tenpaku, Nagoya, Aichi 468-8514, Japan.
* To whom correspondence should be addressed. E-mail: t-fuji{at}doc.medic.mie-u.ac.jp.
Stress causes hypocalcemia and ulcerogenesis in rats. In rats under stressful conditions, a rapid and transient increase in circulating prolactin (PRL) is observed, and this enhanced PRL induces PRL receptors (PRLR) in the choroid plexus of rat brain. In this study we used restraint stress in water (RSW) to elucidate the mechanism by which PRLR in the rat brain mediate the protective effect of PRL against stress-induced hypocalcemia and ulcerogenesis. We show that rat PRL acts through the long form of PRLR (PRLR(L)) in the hypothalamus. This is followed by an increase in PRLR(L) mRNA expression in the choroid plexus of the brain, which provides protection against RSW-induced hypocalcemia and gastric erosions. We also show that PRL induces the expression of PRLR protein and CRF mRNA in the paraventricular nucleus. These results suggest that the PRL levels increase in response to stress and it moves from circulation to cerebrospinal fluid to act on the central nervous system (CNS) and thereby plays an important role in helping to protect against acute stress-induced hypocalcemia and gastric erosions.
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  T. Fujikawa, K. Tamura, T. Kawase, Y. Mori, R. R. Sakai, K. Sakuma, A. Yamaguch, M. Ogata, H. Soya, and K. Nakashima Prolactin Receptor Knockdown in the Rat Paraventricular Nucleus by a Morpholino-Antisense Oligonucleotide Causes Hypocalcemia and Stress Gastric Erosion Endocrinology, August 1, 2005; 146(8): 3471 - 3480. [Abstract] [Full Text] [PDF]
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