help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on June 24, 2004
Endocrinology, doi:10.1210/en.2004-0431
A more recent version of this article appeared on September 1, 2004
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
145/9/4073    most recent
Author Manuscript (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gottsch, M L
Right arrow Articles by Steiner, R A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gottsch, M L
Right arrow Articles by Steiner, R A

Submitted on April 5, 2004
Accepted on June 15, 2004

A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse

M L Gottsch, M J Cunningham, J T Smith, S M Popa, B V Acohido, W F Crowley, S Seminara, D K Clifton, and R A Steiner*

Departments of Physiology & Biophysics (MLG, JTS, MJC, SMP, RAS), Obstetrics & Gynecology (BVA, DKC, RAS), and Biology (RAS), University of Washington, Seattle, WA 98195-7290 and the Massachusetts General Hospital (WFC, SS), Harvard Medical School, Boston, MA 02114

* To whom correspondence should be addressed. E-mail: steiner{at}u.washington.edu.

Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54. Mutations or targeted disruptions in the GPR54 gene cause hypogonadotropic hypogonadism in humans and mice, suggesting that kisspeptin signaling may be important for the regulation of gonadotropin secretion. To examine the effects of kisspeptin-54 (metastin) and kisspeptin-10 (the biologically active C-terminal decapeptide) on gonadotropin secretion in the mouse, we administered the kisspeptins directly into the lateral cerebral ventricle of the brain and demonstrated that both peptides stimulate LH secretion. Further characterization of kisspeptin-54 demonstrated that it stimulated both LH and FSH secretion, at doses as low as 1 fmol; moreover, this effect was shown to be blocked by pretreatment with acyline, a potent gonadotropin-releasing hormone (GnRH) antagonist. To learn more about the functional anatomy of kisspeptins, we mapped the distribution of KiSS-1 mRNA in the hypothalamus. We observed that KiSS-1 mRNA is expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus (AVPV), the periventricular nucleus (PeN), and the arcuate nucleus (Arc). We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH.
Key words: Kisspeptin-54 • metastin • Kisspeptin-10 • KiSS-1 mRNA • Gonadotropins • Hypothalamus • In Situ Hybridization




This article has been cited by other articles:


Home page
 EndocrinologyHome page
X. Liu, K. Lee, and A. E. Herbison
Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels
Endocrinology, September 1, 2008; 149(9): 4605 - 4614.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Ramaswamy, K. A. Guerriero, R. B. Gibbs, and T. M. Plant
Structural Interactions between Kisspeptin and GnRH Neurons in the Mediobasal Hypothalamus of the Male Rhesus Monkey (Macaca mulatta) as Revealed by Double Immunofluorescence and Confocal Microscopy
Endocrinology, September 1, 2008; 149(9): 4387 - 4395.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
X. d'Anglemont de Tassigny, L. A. Fagg, M. B. L. Carlton, and W. H. Colledge
Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals
Endocrinology, August 1, 2008; 149(8): 3926 - 3932.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. L. Keen, F. H. Wegner, S. R. Bloom, M. A. Ghatei, and E. Terasawa
An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo
Endocrinology, August 1, 2008; 149(8): 4151 - 4157.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
C. A Lents, N. L Heidorn, C R. Barb, and J J. Ford
Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts
Reproduction, June 1, 2008; 135(6): 879 - 887.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Roa, E. Vigo, D. Garcia-Galiano, J. M. Castellano, V. M. Navarro, R. Pineda, C. Dieguez, E. Aguilar, L. Pinilla, and M. Tena-Sempere
Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states
Am J Physiol Endocrinol Metab, June 1, 2008; 294(6): E1088 - E1096.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Gonzalez-Martinez, C. De Mees, Q. Douhard, C. Szpirer, and J. Bakker
Absence of Gonadotropin-Releasing Hormone 1 and Kiss1 Activation in {alpha}-Fetoprotein Knockout Mice: Prenatal Estrogens Defeminize the Potential to Show Preovulatory Luteinizing Hormone Surges
Endocrinology, May 1, 2008; 149(5): 2333 - 2340.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Kanda, Y. Akazome, T. Matsunaga, N. Yamamoto, S. Yamada, H. Tsukamura, K.-i. Maeda, and Y. Oka
Identification of KiSS-1 Product Kisspeptin and Steroid-Sensitive Sexually Dimorphic Kisspeptin Neurons in Medaka (Oryzias latipes)
Endocrinology, May 1, 2008; 149(5): 2467 - 2476.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. W. Hill, J. K. Elmquist, and C. F. Elias
Hypothalamic pathways linking energy balance and reproduction
Am J Physiol Endocrinol Metab, May 1, 2008; 294(5): E827 - E832.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Zhang, T. A. Roepke, M. J. Kelly, and O. K. Ronnekleiv
Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels
J. Neurosci., April 23, 2008; 28(17): 4423 - 4434.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Pielecka-Fortuna, Z. Chu, and S. M. Moenter
Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol
Endocrinology, April 1, 2008; 149(4): 1979 - 1986.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. T. Smith, A. Rao, A. Pereira, A. Caraty, R. P. Millar, and I. J. Clarke
Kisspeptin Is Present in Ovine Hypophysial Portal Blood But Does Not Increase during the Preovulatory Luteinizing Hormone Surge: Evidence that Gonadotropes Are Not Direct Targets of Kisspeptin in Vivo
Endocrinology, April 1, 2008; 149(4): 1951 - 1959.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. G. Revel, M. Saboureau, P. Pevet, V. Simonneaux, and J. D. Mikkelsen
RFamide-Related Peptide Gene Is a Melatonin-Driven Photoperiodic Gene
Endocrinology, March 1, 2008; 149(3): 902 - 912.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. S. Kinsey-Jones, X. F. Li, S. M. Luckman, and K. T. O'Byrne
Effects of Kisspeptin-10 on the Electrophysiological Manifestation of Gonadotropin-Releasing Hormone Pulse Generator Activity in the Female Rat
Endocrinology, March 1, 2008; 149(3): 1004 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. T. Phillips and R. D. Palmiter
Role of Agouti-Related Protein-Expressing Neurons in Lactation
Endocrinology, February 1, 2008; 149(2): 544 - 550.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. L. Goodman, M. N. Lehman, J. T. Smith, L. M. Coolen, C. V. R. de Oliveira, M. R. Jafarzadehshirazi, A. Pereira, J. Iqbal, A. Caraty, P. Ciofi, et al.
Kisspeptin Neurons in the Arcuate Nucleus of the Ewe Express Both Dynorphin A and Neurokinin B
Endocrinology, December 1, 2007; 148(12): 5752 - 5760.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Caraty, J. T. Smith, D. Lomet, S. Ben Said, A. Morrissey, J. Cognie, B. Doughton, G. Baril, C. Briant, and I. J. Clarke
Kisspeptin Synchronizes Preovulatory Surges in Cyclical Ewes and Causes Ovulation in Seasonally Acyclic Ewes
Endocrinology, November 1, 2007; 148(11): 5258 - 5267.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. M. Dungan, M. L. Gottsch, H. Zeng, A. Gragerov, J. E. Bergmann, D. K. Vassilatis, D. K. Clifton, and R. A. Steiner
The Role of Kisspeptin GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone
J. Neurosci., October 31, 2007; 27(44): 12088 - 12095.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. S. Dhillo, O. B. Chaudhri, E. L. Thompson, K. G. Murphy, M. Patterson, R. Ramachandran, G. K. Nijher, V. Amber, A. Kokkinos, M. Donaldson, et al.
Kisspeptin-54 Stimulates Gonadotropin Release Most Potently during the Preovulatory Phase of the Menstrual Cycle in Women
J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3958 - 3966.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Li, D. Mitchell, J. Luo, Z. Yi, S.-G. Cho, J. Guo, X. Li, G. Ning, X. Wu, and M. Liu
Estrogen Regulates KiSS1 Gene Expression through Estrogen Receptor {alpha} and SP Protein Complexes
Endocrinology, October 1, 2007; 148(10): 4821 - 4828.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
B. J Todd, G. S Fraley, A. C Peck, G. J Schwartz, and A. M Etgen
Central Insulin-Like Growth Factor 1 Receptors Play Distinct Roles in the Control of Reproduction, Food Intake, and Body Weight in Female Rats
Biol Reprod, September 1, 2007; 77(3): 492 - 503.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. S. Kauffman, J. H. Park, A. A. McPhie-Lalmansingh, M. L. Gottsch, C. Bodo, J. G. Hohmann, M. N. Pavlova, A. D. Rohde, D. K. Clifton, R. A. Steiner, et al.
The Kisspeptin Receptor GPR54 Is Required for Sexual Differentiation of the Brain and Behavior
J. Neurosci., August 15, 2007; 27(33): 8826 - 8835.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. d'Anglemont de Tassigny, L. A. Fagg, J. P. C. Dixon, K. Day, H. G. Leitch, A. G. Hendrick, D. Zahn, I. Franceschini, A. Caraty, M. B. L. Carlton, et al.
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene
PNAS, June 19, 2007; 104(25): 10714 - 10719.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Yamada, Y. Uenoyama, M. Kinoshita, K. Iwata, K. Takase, H. Matsui, S. Adachi, K. Inoue, K.-I. Maeda, and H. Tsukamura
Inhibition of Metastin (Kisspeptin-54)-GPR54 Signaling in the Arcuate Nucleus-Median Eminence Region during Lactation in Rats
Endocrinology, May 1, 2007; 148(5): 2226 - 2232.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. S. Kauffman, M. L. Gottsch, J. Roa, A. C. Byquist, A. Crown, D. K. Clifton, G. E. Hoffman, R. A. Steiner, and M. Tena-Sempere
Sexual Differentiation of Kiss1 Gene Expression in the Brain of the Rat
Endocrinology, April 1, 2007; 148(4): 1774 - 1783.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. Tenenbaum-Rakover, M. Commenges-Ducos, A. Iovane, C. Aumas, O. Admoni, and N. de Roux
Neuroendocrine Phenotype Analysis in Five Patients with Isolated Hypogonadotropic Hypogonadism due to a L102P Inactivating Mutation of GPR54
J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 1137 - 1144.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. J. Greives, A. O. Mason, M.-A. L. Scotti, J. Levine, E. D. Ketterson, L. J. Kriegsfeld, and G. E. Demas
Environmental Control of Kisspeptin: Implications for Seasonal Reproduction
Endocrinology, March 1, 2007; 148(3): 1158 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. T. Smith, C. M. Clay, A. Caraty, and I. J. Clarke
KiSS-1 Messenger Ribonucleic Acid Expression in the Hypothalamus of the Ewe Is Regulated by Sex Steroids and Season
Endocrinology, March 1, 2007; 148(3): 1150 - 1157.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Lee, J. K. Hiney, M. D. Pine, V. K. Srivastava, and W. L. Dees
Manganese stimulates luteinizing hormone releasing hormone secretion in prepubertal female rats: hypothalamic site and mechanism of action
J. Physiol., February 1, 2007; 578(3): 765 - 772.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. J. Mead, J. J. Maguire, R. E. Kuc, and A. P. Davenport
Kisspeptins Are Novel Potent Vasoconstrictors in Humans, with a Discrete Localization of Their Receptor, G Protein-Coupled Receptor 54, to Atherosclerosis-Prone Vessels
Endocrinology, January 1, 2007; 148(1): 140 - 147.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Mastronardi, G. G. Smiley, J. Raber, T. Kusakabe, A. Kawaguchi, V. Matagne, A. Dietzel, S. Heger, A. E. Mungenast, R. Cabrera, et al.
Deletion of the Ttf1 Gene in Differentiated Neurons Disrupts Female Reproduction without Impairing Basal Ganglia Function
J. Neurosci., December 20, 2006; 26(51): 13167 - 13179.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Clarkson and A. E. Herbison
Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons
Endocrinology, December 1, 2006; 147(12): 5817 - 5825.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
F. Cerrato, J. Shagoury, M. Kralickova, A. Dwyer, J. Falardeau, M. Ozata, G. Van Vliet, P. Bouloux, J. E Hall, F. J Hayes, et al.
Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism
Eur. J. Endocrinol., November 1, 2006; 155(suppl_1): S3 - S10.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. S. Dhillo, P. Savage, K. G. Murphy, O. B. Chaudhri, M. Patterson, G. M. Nijher, V. M. Foggo, G. S. Dancey, H. Mitchell, M. J. Seckl, et al.
Plasma kisspeptin is raised in patients with gestational trophoblastic neoplasia and falls during treatment
Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E878 - E884.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. L. Thompson, K. G. Murphy, M. Patterson, G. A. Bewick, G. W. H. Stamp, A. E. Curtis, J. H. Cooke, P. H. Jethwa, J. F. Todd, M. A. Ghatei, et al.
Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats
Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E1074 - E1082.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. M. Castellano, V. M. Navarro, R. Fernandez-Fernandez, J. Roa, E. Vigo, R. Pineda, C. Dieguez, E. Aguilar, L. Pinilla, and M. Tena-Sempere
Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats
Diabetes, September 1, 2006; 55(9): 2602 - 2610.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
M. Tena-Sempere
GPR54 and kisspeptin in reproduction
Hum. Reprod. Update, September 1, 2006; 12(5): 631 - 639.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. T. Smith, S. M. Popa, D. K. Clifton, G. E. Hoffman, and R. A. Steiner
Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge.
J. Neurosci., June 21, 2006; 26(25): 6687 - 6694.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Tovar, M. J. Vazquez, V. M. Navarro, R. Fernandez-Fernandez, J. M. Castellano, E. Vigo, J. Roa, F. F. Casanueva, E. Aguilar, L. Pinilla, et al.
Effects of Single or Repeated Intravenous Administration of Kisspeptin upon Dynamic LH Secretion in Conscious Male Rats
Endocrinology, June 1, 2006; 147(6): 2696 - 2704.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Roa, E. Vigo, J. M. Castellano, V. M. Navarro, R. Fernandez-Fernandez, F. F. Casanueva, C. Dieguez, E. Aguilar, L. Pinilla, and M. Tena-Sempere
Hypothalamic Expression of KiSS-1 System and Gonadotropin-Releasing Effects of Kisspeptin in Different Reproductive States of the Female Rat
Endocrinology, June 1, 2006; 147(6): 2864 - 2878.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. B. Seminara, M. J. DiPietro, S. Ramaswamy, W. F. Crowley Jr., and T. M. Plant
Continuous Human Metastin 45-54 Infusion Desensitizes G Protein-Coupled Receptor 54-Induced Gonadotropin-Releasing Hormone Release Monitored Indirectly in the Juvenile Male Rhesus Monkey (Macaca mulatta): A Finding with Therapeutic Implications
Endocrinology, May 1, 2006; 147(5): 2122 - 2126.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
J. T Smith, D. K Clifton, and R. A Steiner
Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling.
Reproduction, April 1, 2006; 131(4): 623 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, and C. Y. Bowers
Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition
Endocr. Rev., April 1, 2006; 27(2): 101 - 140.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. R. Ojeda, A. Lomniczi, C. Mastronardi, S. Heger, C. Roth, A.-S. Parent, V. Matagne, and A. E. Mungenast
Minireview: The Neuroendocrine Regulation of Puberty: Is the Time Ripe for a Systems Biology Approach?
Endocrinology, March 1, 2006; 147(3): 1166 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. M. Dungan, D. K Clifton, and R. A. Steiner
Minireview: Kisspeptin Neurons as Central Processors in the Regulation of Gonadotropin-Releasing Hormone Secretion
Endocrinology, March 1, 2006; 147(3): 1154 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Pompolo, A. Pereira, K. M. Estrada, and I. J. Clarke
Colocalization of Kisspeptin and Gonadotropin-Releasing Hormone in the Ovine Brain
Endocrinology, February 1, 2006; 147(2): 804 - 810.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. M. Plant, S. Ramaswamy, and M. J. DiPietro
Repetitive Activation of Hypothalamic G Protein-Coupled Receptor 54 with Intravenous Pulses of Kisspeptin in the Juvenile Monkey (Macaca mulatta) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges
Endocrinology, February 1, 2006; 147(2): 1007 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S.-K. Han, M. L. Gottsch, K. J. Lee, S. M. Popa, J. T. Smith, S. K. Jakawich, D. K. Clifton, R. A. Steiner, and A. E. Herbison
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
J. Neurosci., December 7, 2005; 25(49): 11349 - 11356.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. B. Seminara
We All Remember Our First Kiss: Kisspeptin and the Male Gonadal Axis
J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6738 - 6740.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. S. Dhillo, O. B. Chaudhri, M. Patterson, E. L. Thompson, K. G. Murphy, M. K. Badman, B. M. McGowan, V. Amber, S. Patel, M. A. Ghatei, et al.
Kisspeptin-54 Stimulates the Hypothalamic-Pituitary Gonadal Axis in Human Males
J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6609 - 6615.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. C. Arai, Y.-F. Xia, E. Suzuki, M. Kessler, O. Civelli, and H.-P. Nothacker
Cancer Metastasis-Suppressing Peptide Metastin Upregulates Excitatory Synaptic Transmission in Hippocampal Dentate Granule Cells
J Neurophysiol, November 1, 2005; 94(5): 3648 - 3652.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Wettschureck and S. Offermanns
Mammalian G Proteins and Their Cell Type Specific Functions
Physiol Rev, October 1, 2005; 85(4): 1159 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Kinoshita, H. Tsukamura, S. Adachi, H. Matsui, Y. Uenoyama, K. Iwata, S. Yamada, K. Inoue, T. Ohtaki, H. Matsumoto, et al.
Involvement of Central Metastin in the Regulation of Preovulatory Luteinizing Hormone Surge and Estrous Cyclicity in Female Rats
Endocrinology, October 1, 2005; 146(10): 4431 - 4436.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Tena-Sempere
Hypothalamic KiSS-1: The Missing Link in Gonadotropin Feedback Control?
Endocrinology, September 1, 2005; 146(9): 3683 - 3685.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
J. T. Smith, M. J. Cunningham, E. F. Rissman, D. K Clifton, and R. A. Steiner
Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse
Endocrinology, September 1, 2005; 146(9): 3686 - 3692.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. M. Castellano, V. M. Navarro, R. Fernandez-Fernandez, R. Nogueiras, S. Tovar, J. Roa, M. J. Vazquez, E. Vigo, F. F. Casanueva, E. Aguilar, et al.
Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition
Endocrinology, September 1, 2005; 146(9): 3917 - 3925.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. T. Smith, H. M. Dungan, E. A. Stoll, M. L. Gottsch, R. E. Braun, S. M. Eacker, D. K Clifton, and R. A. Steiner
Differential Regulation of KiSS-1 mRNA Expression by Sex Steroids in the Brain of the Male Mouse
Endocrinology, July 1, 2005; 146(7): 2976 - 2984.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. B. Seminara and U. B. Kaiser
New Gatekeepers of Reproduction: GPR54 and Its Cognate Ligand, KiSS-1
Endocrinology, April 1, 2005; 146(4): 1686 - 1688.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
V. M. Navarro, J. M. Castellano, R. Fernandez-Fernandez, S. Tovar, J. Roa, A. Mayen, M. L. Barreiro, F. F. Casanueva, E. Aguilar, C. Dieguez, et al.
Effects of KiSS-1 Peptide, the Natural Ligand of GPR54, on Follicle-Stimulating Hormone Secretion in the Rat
Endocrinology, April 1, 2005; 146(4): 1689 - 1697.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.