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Submitted on April 19, 2004
Accepted on June 23, 2004
-INTERFERON AND DOUBLE STRAND POLYNUCLEOTIDES*
Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Section of Medical Oncology, Department of Oncology and Neurosciences and Section of Endocrinology, Department of Medicine and Science of Aging, Università degli Studi "G. D'Annunzio", Faculty of Medicine and Surgery, 66100 Chieti, Italy; Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 and Edison Biotechnology Institute, Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, OH 45701
* To whom correspondence should be addressed. E-mail: iacobell{at}unich.it.
Here we report the cloning of the rat 90K, a homolog of the mouse CyCAP/MAMA and human 90K. The protein is constitutively expressed by FRTL-5 thyrocytes and its levels are modulated by TSH, insulin/IGF-1 and 
-IFN. Transfection of the cells with 90K cDNA or exposure to purified 90K resulted in a significant increase of the expression of major histocompatibility (MHC) class I, but not class II antigens. An increased expression of 90K was obtained after viral infection or introduction into the cells of fragments of viral, bacterial, or mammalian double-strand (ds) polynucleotides. The increase was sequence-independent, not CpG mediated, and associated with the expression of molecules characterizing antigen-presenting-cell phenotype. The present data along with results from previous studies suggest that 90K plays an important role in the maintenance of an appropriate level of immune response.
-IFN
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