| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on April 22, 2004
Accepted on July 13, 2004
Pharmacology Department, Amylin Pharmaceuticals, Inc., 9360 Towne Centre Drive, San Diego, CA 92121, U.S.A. and Division of Gastroenterology, Tufts-New England Medical Center, Boston, MA 02111, U.S.A.
* To whom correspondence should be addressed. E-mail: sadams{at}amylin.com.
The gut-derived hormones PYY[3-36] and ghrelin are believed to influence similar hypothalamic circuits, albeit with opposing actions on energy balance. Thus, we carried out a series of studies to evaluate the interaction of these hormones on short-term food intake responses in mice. Intraperitoneal (i.p.) PYY[3-36] injection reduced short-term food intake by up to 50% in overnight-fasted mice and in postabsorptive animals during the early and late light cycle. This effect was not sensitive to the prevailing endogenous plasma acyl-ghrelin concentrations, which ranged from the high physiologic (overnight-fasted, 1252 ± 108 pg/mL) to low levels (late light cycle, 402 ± 33 pg/mL). PYY[3-36] administration did not reduce plasma total or acyl-ghrelin concentration in conjunction with its anorexigenic actions. Ghrelin increased short-term food intake by up to 1.8-fold in mice treated i.p. in the early light cycle, but was ineffective in animals treated following an overnight fast or during the late light cycle. Ghrelin did not increase food intake or growth hormone secretion unless plasma levels were increased above high physiologic fasting values. The anorexigenic effect of PYY[3-36] over a range of doses was not compromised by co-injection of ghrelin, and PYY[3-36] reduced food intake in agouti mice which lack fully-functional melanocortin signaling. These results in mice support a model in which (a) PYY[3-36] diminishes short-term food intake, at least in part, through mechanisms distinct from the NPY/POMC neural circuits engaged by ghrelin, and (b) a reduction in circulating ghrelin is not requisite for the anorexigenic effects of PYY[3-36].
This article has been cited by other articles:
 |
|
 |
|
  S. Unniappan and T. J. Kieffer Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R51 - R58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. E F Crowley Overview of human obesity and central mechanisms regulating energy homeostasis Ann Clin Biochem, May 1, 2008; 45(3): 245 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. T. Parlevliet, A. C. Heijboer, J. P. Schroder-van der Elst, L. M. Havekes, J. A. Romijn, H. Pijl, and E. P. M. Corssmit Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E142 - E147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J Little, M. Horowitz, and C. Feinle-Bisset Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity Am. J. Clinical Nutrition, September 1, 2007; 86(3): 531 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. G. Murphy, W. S. Dhillo, and S. R. Bloom Gut Peptides in the Regulation of Food Intake and Energy Homeostasis Endocr. Rev., December 1, 2006; 27(7): 719 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Chelikani, A. C. Haver, and R. D. Reidelberger Ghrelin Attenuates the Inhibitory Effects of Glucagon-Like Peptide-1 and Peptide YY(3-36) on Food Intake and Gastric Emptying in Rats Diabetes, November 1, 2006; 55(11): 3038 - 3046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ito, H. ThidarMyint, T. Murata, H. Inoue, R. M. Neyra, and H. Kuwayama Effects of peripheral administration of PYY3-36 on feed intake and plasma acyl-ghrelin levels in pigs. J. Endocrinol., October 1, 2006; 191(1): 113 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Bacha and S. A. Arslanian Ghrelin and Peptide YY in Youth: Are There Race-Related Differences? J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 3117 - 3122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Young Obesity: A Peptide YY-Deficient, But Not Peptide YY- Resistant, State Endocrinology, January 1, 2006; 147(1): 1 - 2. [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Adams, C. Lei, C. M. Jodka, S. E. Nikoulina, J. A. Hoyt, B. Gedulin, C. M. Mack, and E. S. Kendall PYY[3-36] Administration Decreases the Respiratory Quotient and Reduces Adiposity in Diet-Induced Obese Mice J. Nutr., January 1, 2006; 136(1): 195 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Siahanidou, H. Mandyla, M. Vounatsou, D. Anagnostakis, I. Papassotiriou, and G. P. Chrousos Circulating Peptide YY Concentrations Are Higher in Preterm than Full-Term Infants and Correlate Negatively with Body Weight and Positively with Serum Ghrelin Concentrations Clin. Chem., November 1, 2005; 51(11): 2131 - 2137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Talsania, Y. Anini, S. Siu, D. J. Drucker, and P. L. Brubaker Peripheral Exendin-4 and Peptide YY3-36 Synergistically Reduce Food Intake through Different Mechanisms in Mice Endocrinology, September 1, 2005; 146(9): 3748 - 3756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schonhoff, L. Baggio, C. Ratineau, S. K. Ray, J. Lindner, M. A. Magnuson, D. J. Drucker, and A. B. Leiter Energy Homeostasis and Gastrointestinal Endocrine Differentiation Do Not Require the Anorectic Hormone Peptide YY Mol. Cell. Biol., May 15, 2005; 25(10): 4189 - 4199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Chelikani, A. C. Haver, and R. D. Reidelberger Intravenous Infusion of Peptide YY(3-36) Potently Inhibits Food Intake in Rats Endocrinology, February 1, 2005; 146(2): 879 - 888. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
