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This version published online on July 22, 2004
Endocrinology, doi:10.1210/en.2004-0806
A more recent version of this article appeared on November 1, 2004
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Submitted on June 28, 2004
Accepted on July 16, 2004

A possible mechanism for the action of adrenomedullin in brain to stimulate stress hormone secretion

Meghan M. Taylor* and Willis K. Samson

Saint Louis University, Department of Pharmacological and Physiological Science, 1402 S. Grand Boulevard, St. Louis, MO 63104

* To whom correspondence should be addressed. E-mail: taylormm{at}slu.edu.

Adrenomedullin (AM) has been reported to have actions at each level of the hypothalamo-pituitary-adrenal (HPA) axis suggesting that the peptide plays a role in the organization of the neuroendocrine responses to stress. We examined the mechanism by which AM regulates the central nervous system branch of the HPA axis, as well as the possible role of AM in the modulation of the releases of two other hormones, prolactin and growth hormone, whose secretions also are altered by stress. Intracerebroventricular (i.c.v.) administration of AM led to elevated plasma corticosterone levels in unrestrained, conscious male rats. This effect was abrogated by pretreatment with a CRH antagonist, suggesting that AM activates the HPA axis by causing the release of CRH into hypophyseal portal vessels. In addition, AM given i.c.v. stimulated the release of prolactin but did not alter the secretion of growth hormone. We propose that AM produced in the brain may be an important neuromodulator of the hormonal stress response.
Key words: corticosterone • CRH • prolactin • growth hormone




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