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Submitted on July 16, 2004
Accepted on August 9, 2004
Dipartimento di Biologia e Patologia Cellulare e Molecolare, University ‘Federico II’ c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Naples, Italy
* To whom correspondence should be addressed. E-mail: masantor{at}unina.it.
The RET gene encodes a single-pass transmembrane receptor tyrosine kinase. RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. The latter may arise as a component of multiple endocrine neoplasia type 2 (MEN 2) syndromes; germline mutations in RET are responsible for MEN 2 inheritance. Here we review data on the mechanisms leading to RET oncogenic conversion, and on RET targeting as a strategy in thyroid cancer treatment.
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