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Submitted on August 2, 2004
Accepted on October 21, 2004
Departments of Biochemistry and Molecular Biology, Pharmacologyand Cell Biology. Faculty of Medicine. University of Murcia. 30100 Murcia. Spain
* To whom correspondence should be addressed. E-mail: rapegar{at}um.es.
LH plays a relevant role in folliculogenesis, ovulation and luteinization. Although ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is a target of LH in the ovary, the functional significance of ODC induction has remained elusive. Our study reveals that the blockade of the induction of ovarian ODC by means of the specific inhibitor 
-difluoromethylornithine (DFMO) affects folliculogenesis and luteinization. In immature female mice DFMO was found to inhibit ovarian growth, the formation of Graafian follicles and the secretion of progesterone and estradiol In adult cycling females, the administration of DFMO at the evening/night of proestrus, markedly decreased plasma progesterone levels at diestrus, what was associated to the decrease in the expression of steroidogenic factor 1, cytochrome P450scc enzyme and StAR protein in the ovary, and to a reduced vascularization of the corpora lutea. These effects were not reverted by the administration of gonadotropins or prolactin. ODC immunoreactivity was also stimulated by LH in theca and granulosa cells of antral follicles but not in preantral follicles. In overall, these experiments demonstrate that elevated ODC values found in the ovary of immature and adult mice play a relevant function in ovarian physiology, and that ODC/polyamines must be considered as important mediators of some of the effects of LH on follicular development and luteinization.
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