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This version published online on May 26, 2005
Endocrinology, doi:10.1210/en.2005-0502
A more recent version of this article appeared on September 1, 2005
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Submitted on April 27, 2005
Accepted on May 19, 2005

The telomerase activity of adult mouse testis resides in the spermatogonial {alpha}6-integrin-positive Side Population enriched in germinal stem cells

Lydia Riou, Henri Bastos, Bruno Lassalle, Mathieu Coureuil, Jacques Testart, François D. Boussin, Isabelle Allemand, and Pierre Fouchet*

Laboratoire Gamétogenèse, Apoptose et Génotoxicité/INSERM U566/Département de Radiobiologie et Radiopathologie, Direction des Sciences du Vivant, CEA, 92265 Fontenay aux Roses, France.; Laboratoire de Radiopathologie, Département de Radiobiologie et Radiopathologie, Direction des Sciences du Vivant, CEA, 92265 Fontenay aux Roses, France

* To whom correspondence should be addressed. E-mail: pierre.fouchet{at}cea.fr.

Testis is one of the organs with the most telomerase activity in the adult. This activity protects chromosomes from telomere attrition and ensures the transmission of full-length chromosomes to progeny. Little is known about telomerase activity during adult germ cell differentiation, however. We demonstrate here that the telomerase activity of adult mouse testis resides in the {alpha}6-integrin-positive Side Population containing spermatogonia and enriched in spermatogonial stem cells. The telomerase activity of these cells fell upon entry into meiosis and during the subsequent spermiogenesis. In addition, the telomerase activity of cells in various stages of differentiation was unaffected by aging and, notably, remained high in the {alpha}6-integrin-positive Side Population.
Key words: Telomerase • testis • Side Population • spermatogenesis • aging






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