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This version published online on September 22, 2005
Endocrinology, doi:10.1210/en.2005-0662
A more recent version of this article appeared on January 1, 2006
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Submitted on June 1, 2005
Accepted on September 15, 2005

Gonadotropin-Releasing Hormone II Stimulates Female Sexual Behavior in Marmoset Monkeys

Deborah K. Barnett*, Tina M Bunnell, Robert P Millar, and David H. Abbott

National Primate Research Center, University of Wisconsin, Madison, WI, 53715; Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, 53792; Endocrinology-Reproductive Physiology Training Program, University of Wisconsin, Madison WI 53706; MRC Human Reproduction Sciences Unit, Edinburgh, EH3 9ET, Scotland, UK

* To whom correspondence should be addressed. E-mail: dbarnett{at}primate.wisc.edu.

GnRH II (pGlu-His-Trp-Ser-Try-Gly-Leu-Arg-Pro-GlyNH2) an evolutionarily conserved member of the gonadotropin-releasing hormone family, stimulates reproductive behavior in a number of vertebrates. To explore a role for GnRH II in regulating primate sexual behavior, 8 adult female common marmosets, each fitted with an indwelling intracerebroventricular (i.c.v.) cannula, were ovariectomized, implanted subcutaneously with empty (n = 4) or estradiol-filled (n = 4) silastic capsules and pair-housed with an adult male mate. After i.c.v. infusion of vehicle or peptides, females were placed in an observation cage for 90 min, out of visual contact with other marmosets, before the 30-min behavioral test with their male partner. Compared with vehicle, GnRH II (1 and 10 µg) increased the total number of proceptive (sexual solicitation) behaviors (tongue flicking, proceptive stares and frozen postures) exhibited by females toward their pair-mates, and specifically increased the frequency of freeze postures. Effects were maximal at 1 µg and not dependent upon estradiol supplementation. GnRH II agonists/GnRH I antagonists 135-18 (1 µg) and 132-25 (1 µg), which stimulate inositol phosphate production via the marmoset type II receptor, increased the frequency of total proceptive behavior, but did not specifically stimulate freeze posture behavior. In contrast GnRH I, at 1 µg, did not alter the frequency of proceptive behaviors. Female receptivity (female compliance with male sexual behavior) was not altered by any of the peptides tested. These findings implicate a role for GnRH II and the cognate GnRH type II receptor in stimulating female marmoset sexual behavior.
Key words: GnRH I • GnRH II • Primate • Receptivity • Proceptivity • Sexual Behavior • Common Marmoset • GnRH Type II Receptors




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