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This version published online on November 3, 2005
Endocrinology, doi:10.1210/en.2005-0679
A more recent version of this article appeared on February 1, 2006
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Submitted on June 6, 2005
Accepted on October 25, 2005

Thioredoxin-binding protein-2 (TBP-2)-like inducible membrane protein (TLIMP) is a novel Vitamin D3 and PPAR-{gamma} ligand target protein that regulates PPAR-{gamma} signaling

Shin-ichi Oka, Hiroshi Masutani*, Wenrui Liu, Hiroyuki Horita, Dongmei Wang, Shinae Kizaka-Kondoh, and Junji Yodoi

Institute for Virus Research, Kyoto University, 53 Shogoin, Kawahara-cho, Sakyo, Kyoto 606-8507, Department of Therapeutic Radiology and Oncology, Kyoto University Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo, Kyoto 606-8501

* To whom correspondence should be addressed. E-mail: hmasutan{at}virus.kyoto-u.ac.jp.

Thioredoxin binding protein-2 (TBP-2), which is identical to Vitamin D3 (VD3) up-regulated protein 1 (VDUP1), plays a crucial role in the integration of glucose and lipid metabolism. There are three highly homologous genes of TBP-2/VDUP1 in humans, but their functions remain unclear. Here, we characterized a TBP-2 homologue, TLIMP (TBP-2 like inducible membrane protein). In contrast to TBP-2, TLIMP displayed no significant binding affinity for thioredoxin. TLIMP exhibited an inner membrane-associated pattern of distribution, and also co-localized with transferrin and low density lipoprotein, indicating endosome- and lysosome-associated functions. VD3 and ligands of peroxisome proliferator-activated receptor-{gamma} (PPAR-{gamma}), an important regulator of energy metabolism and cell growth inhibition, induced the expression of TLIMP as well as TBP-2. Overexpression of TLIMP suppressed both anchorage-dependent and -independent cell growth and PPAR-{gamma} ligand-inducible gene activation. These results suggest that TLIMP, a novel VD3- or PPAR-{gamma} ligand-inducible membrane-associated protein, plays a regulatory role in cell proliferation and PPAR-{gamma} activation.
Key words: Thioredoxin-binding protein-2 like inducible membrane protein (TLIMP) • TBP-2/VDUP1 • vitamin D3 • peroxisome proliferator-activated receptors (PPARs) • endosome






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