help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on November 10, 2005
Endocrinology, doi:10.1210/en.2005-0791
A more recent version of this article appeared on February 1, 2006
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
147/2/647    most recent
Author Manuscript (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Udagawa, J.
Right arrow Articles by Otani, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Udagawa, J.
Right arrow Articles by Otani, H.

Submitted on June 28, 2005
Accepted on November 1, 2005

The role of leptin in the development of the cerebral cortex in mouse embryos

Jun Udagawa*, Ryuju Hashimoto, Hiroaki Suzuki, Toshihisa Hatta, Yusuke Sotomaru, Kyoji Hioki, Yukiko Kagohashi, Tatsuji Nomura, Yasuhiro Minami, and Hiroki Otani

Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan; Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Central Institute for Experimental Animals, Kawasaki 216-0001, Japan; Department of Food Science, Shimane Women's College, Matsue 690-0044, Japan; Department of Genome Sciences, Faculty of Medical Sciences, Kobe University, Graduate School of Medicine, Kobe 650-0017, Japan

* To whom correspondence should be addressed. E-mail: jun{at}med.shimane-u.ac.jp.

Leptin is detected in the sera and leptin receptors are expressed in the cerebrum of mouse embryos, suggesting that leptin plays a role in cerebral development. Compared with the wild-type, leptin-deficient (ob/ob) mice had fewer cells at embryonic day (E) 16 and E18 and had fewer BrdU+ cells at E14 and E16 in the neuroepithelium (NE). Intracerebroventricular leptin injection in E14 ob/ob embryos increased the number of NE cells at E16. In cultured neurosphere cells, leptin treatment increased Hes1 mRNA expression and maintained neural progenitors. Astrocyte differentiation was induced by low-dose (0.1 µg/ml) but not high-dose (1 µg/ml) leptin. High-dose leptin decreased Id mRNA and increased Ngn1 mRNA in neurosphere cells. The NPY mRNA level in the cortical plate was lower in ob/ob than in the wild-type at E16 and E18. These results suggest that leptin maintains neural progenitors and is related to glial and neuronal development in embryos.
Key words: leptin • cerebral cortex • neural progenitor • mice • embryo




This article has been cited by other articles:


Home page
 EndocrinologyHome page
W. Pan, H. Hsuchou, Y. He, A. Sakharkar, C. Cain, C. Yu, and A. J. Kastin
Astrocyte Leptin Receptor (ObR) and Leptin Transport in Adult-Onset Obese Mice
Endocrinology, June 1, 2008; 149(6): 2798 - 2806.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. G. Bouret
Crossing the Border: Developmental Regulation of Leptin Transport to the Brain
Endocrinology, March 1, 2008; 149(3): 875 - 876.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
C. V. Mobbs
Fathead: The Gain in Brain Falls Mainly with Leptin Wane
Endocrinology, February 1, 2006; 147(2): 645 - 646.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society